4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

Base Information

Chemical Name:4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan
CAS No.:879873-88-8
Molecular Formula:C₂₉H₅₀O₅Si
Molecular Weight:506.798
Hs Code.:

Synonyms:4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

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Chemical Property of 4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

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Technology Process of 4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

There total 10 articles about 4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 879873-87-7
(1S,3S,5S,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-6-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-heptane-3,5-diol

: 77-76-9
2,2-dimethoxy-propane

: 879873-88-8
4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/ol052851n

Reference yield:

: 879873-85-5
4-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)butan-2-one

: 879873-88-8
4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

Guidance literature:: Multi-step reaction with 3 steps

1.1: iPr₂NEt; Bu₂BOTf / diethyl ether / 2 h / -78 °C

1.2: 93 percent / H₂O₂ / ethanol; methanol / 1 h / 20 °C / pH 7

2.1: 95 percent / Me₄NB(OAc)3H; AcOH / acetonitrile / 48 h / -20 °C

3.1: 83 percent / PPTS / CH₂Cl₂ / 5 h / 20 °C

With di-n-butylboryl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; acetic acid; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride; In diethyl ether; dichloromethane; acetonitrile; 1.1: aldol reaction;
DOI:10.1021/ol052851n

Reference yield:

: 879873-84-4
1-Methoxy-4-[(S)-3-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-but-3-enyloxymethyl]-benzene

: 879873-88-8
4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; O₃ / methanol / -78 °C

1.2: 96 percent / Me₂S / methanol / 4 h / -78 - 20 °C

2.1: iPr₂NEt; Bu₂BOTf / diethyl ether / 2 h / -78 °C

2.2: 93 percent / H₂O₂ / ethanol; methanol / 1 h / 20 °C / pH 7

3.1: 95 percent / Me₄NB(OAc)3H; AcOH / acetonitrile / 48 h / -20 °C

4.1: 83 percent / PPTS / CH₂Cl₂ / 5 h / 20 °C

With pyridine; di-n-butylboryl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride; In methanol; diethyl ether; dichloromethane; acetonitrile; 2.1: aldol reaction;
DOI:10.1021/ol052851n