tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Base Information

Chemical Name:tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate
CAS No.:885032-76-8
Molecular Formula:C₁₈H₂₃F₂N₃O
Molecular Weight:335.397
Hs Code.:

Synonyms:tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Suppliers and Price of tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

There total 10 articles about tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: 885032-74-6
tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-hydroxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

: 885032-76-8
tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Guidance literature:: With methanesulfonic acid; at 60 ℃;
DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

: 885032-39-3
di-tert-butyl (3-hydroxy-3-methyl-2-oxobutyl)imidodicarbonate

: 885032-76-8
tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / methanol

2: triethylamine; mercury dichloride / ethanol / 60 °C

3: methanesulfonic acid / 60 °C

With hydrogenchloride; methanesulfonic acid; water; triethylamine; mercury dichloride; In methanol; ethanol;
DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

: 885033-77-2
1-amino-3-hydroxy-3-methylbutan-2-one hydrochloride

: 885032-76-8
tert-butyl (6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; mercury dichloride / ethanol / 60 °C

2: methanesulfonic acid / 60 °C

With methanesulfonic acid; triethylamine; mercury dichloride; In ethanol;
DOI:10.1016/j.bmcl.2010.12.054