Technology Process of Phosphinic acid, [(2R,3S)-4-hydroxy-2,3-dimethoxybutyl]phenyl-, ethyl
ester
There total 5 articles about Phosphinic acid, [(2R,3S)-4-hydroxy-2,3-dimethoxybutyl]phenyl-, ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
ethanol;
at 20 ℃;
for 6h;
DOI:10.3987/COM-05-S(K)15
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 93 percent / 3 h / 150 °C
2: 92 percent / H2 / Pd(OH)2/C / ethanol / 6 h / 20 °C
With
hydrogen;
palladium dihydroxide;
In
ethanol;
1: Michaelis-Arbuzov reaction;
DOI:10.3987/COM-05-S(K)15
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / 1,2-dimethoxy-ethane / 1 h / 20 °C
1.2: 80 percent / 1,2-dimethoxy-ethane / 8 h / 20 °C
2.1: 55 percent / carbon tetrabromide; triphenylphosphine / CHCl3 / 6 h / 0 - 5 °C
3.1: 93 percent / 3 h / 150 °C
4.1: 92 percent / H2 / Pd(OH)2/C / ethanol / 6 h / 20 °C
With
carbon tetrabromide; hydrogen; sodium hydride; triphenylphosphine;
palladium dihydroxide;
In
1,2-dimethoxyethane; ethanol; chloroform;
3.1: Michaelis-Arbuzov reaction;
DOI:10.3987/COM-05-S(K)15
