Technology Process of 2-Butenoic acid, 2-methyl-4-[[(phenylmethoxy)carbonyl]amino]-,
1,1-dimethylethyl ester, (2Z)-
There total 2 articles about 2-Butenoic acid, 2-methyl-4-[[(phenylmethoxy)carbonyl]amino]-,
1,1-dimethylethyl ester, (2Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl α-(diethoxyphosphinyl)propionate;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
N-benzyloxycarbonylglycinal;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 3h;
DOI:10.1016/j.tet.2005.11.051
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium aluminium hydride / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C
1.2: KHSO4 / H2O
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: tetrahydrofuran; hexane / 1.75 h / -78 - 20 °C
With
lithium aluminium tetrahydride; n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1016/j.tet.2005.11.051
- Guidance literature:
-
Multi-step reaction with 4 steps
1: AD-mix-β; methane sulfonamide / H2O; 2-methyl-propan-2-ol / 48 h / 0 - 20 °C
2: hydrogen / Pd/C / methanol / 12 h / 20 °C / 22501.8 Torr
3: 80 percent / triethylamine; benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-) / dimethylformamide / 2 h / 25 °C / pH 9 - 10
4: 98 percent / trifluoroacetic acid / 0.5 h / 25 °C
With
methanesulfonamide; AD-mix-β; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2005.11.051
