Benzyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate

Base Information

• Chemical Name: Benzyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate
• CAS No.: 121505-94-0
• Molecular Formula: C12H16N2O4
• Molecular Weight: 252.27
• Hs Code.: 2924299090
• European Community (EC) Number: 629-568-3
• Nikkaji Number: J1.945.081C
• ChEMBL ID: CHEMBL77240
• Mol file: 121505-94-0.mol

Synonyms:121505-94-0;Benzyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate;N-alpha-Cbz-glycine N-methoxy-N-methylamide;benzyl N-[2-[methoxy(methyl)amino]-2-oxoethyl]carbamate;BENZYL N-{[METHOXY(METHYL)CARBAMOYL]METHYL}CARBAMATE;CHEMBL77240;SCHEMBL764273;NWYPLKICSHBTAJ-UHFFFAOYSA-N;WEA50594;MFCD09997727;AKOS015968680;SB31847;AM803047;N-alpha-Cbz-Glycine N-methoxy-N-metylamide;CS-0038312;FT-0730029;EN300-7049197;benzyl 2-(methoxy(methyl)amino)-2-oxoethylcarbamate;Benzyl(2-(methoxy(methyl)amino)-2-oxoethyl)carbamate;N-Methoxy-N-methyl-2-(benzyloxycarbonylamino)acetamide;N-Alpha-Cbz-glycine N-methoxy-N-methylamide, AldrichCPR

Chemical Property of Benzyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate

Chemical Property:

• PSA: 71.36000
• LogP: 1.13700
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 252.11100700
• Heavy Atom Count: 18
• Complexity: 277

Purity/Quality:

97% ^*data from raw suppliers

BenzylN-[2-[Methoxy(methyl)amino]-2-oxoethyl]carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C(=O)CNC(=O)OCC1=CC=CC=C1)OC

Technology Process of Benzyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate

There total 5 articles about Benzyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide (121505-94-0)

Guidance literature:

With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.52.470

Reference yield: 93.0%

1-((N,O-dimethylhydroxylamino)carbonyl)-1H-imidazole + N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide (121505-94-0)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; chemoselective reaction; Inert atmosphere; Sealed vial;

DOI:10.1016/j.tet.2011.09.057

Reference yield: 93.0%

N-(Benzyloxycarbonyl)glycine (1138-80-3) + 1-{[methoxy(methyl)amino]-carbonyl}-3-methyl-1H-imidazol-3-ium iodide → N-benzyloxycarbonyl-glycine-N'-methoxy-N'-methylamide (121505-94-0)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 16h;

DOI:10.1016/j.tetlet.2003.08.026 DOI:10.1016/j.tet.2005.05.056

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

N-(Benzyloxycarbonyl)glycine

N,0-dimethylhydroxylamine

benzyl chloroformate

Downstream raw materials:

N-benzyloxycarbonylglycinal

t-butyl-4-[(benzyloxycarbonyl)amino]-2-methyl-2-butanoate

t-butyl-4-[(benzyloxycarbonyl)amino]-2-methyl-2-butanoate

(2R,3R)-tert-butyl 4-((benzyloxycarbonyl)amino)-2,3-dihydroxy-2-methylbutanoate