3-chloro-N-methyl-N-phenylpropanamide

Base Information

• Chemical Name: 3-chloro-N-methyl-N-phenylpropanamide
• CAS No.: 89585-53-5
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Hs Code.: 2924299090
• Mol file: 89585-53-5.mol

Synonyms:3-chloro-N-methyl-N-phenylpropanamide;

Chemical Property of 3-chloro-N-methyl-N-phenylpropanamide

Chemical Property:

• Vapor Pressure: 0.00226mmHg at 25°C
• Boiling Point: 289oC at 760 mmHg
• Flash Point: 128.6oC
• PSA: 20.31000
• Density: 1.169g/cm3
• LogP: 2.27830

Purity/Quality:

97% ^*data from raw suppliers

3-chloro-N-methyl-N-phenylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-N-methyl-N-phenylpropanamide

There total 1 articles about 3-chloro-N-methyl-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloropropionyl chloride (625-36-5) + N-methylaniline (100-61-8) → 3-chloro-N-methyl-N-phenylpropanamide (89585-53-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield: 87.0%

3-chloro-N-methyl-N-phenylpropanamide (89585-53-5) → 3-azido-N-methyl-N-phenylpropanamide

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield: 80.0%

3-chloro-N-methyl-N-phenylpropanamide (89585-53-5) + phenylboronic acid (98-80-6) → N-methyl-N-phenyl-3-phenylpropanamide (18859-20-6)

Guidance literature:

With potassium phosphate; Wilkinson's catalyst; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;

DOI:10.1002/adsc.201200821

upstream raw materials:

2-chloropropionyl chloride

N-methylaniline

Downstream raw materials:

N-methyl-N-phenylacrylamide

N-methyl-N-phenyl-3-phenylpropanamide