Carbamic acid, [5-[(phenylamino)carbonyl]-1H-benzimidazol-2-yl]-, ethyl ester

Base Information

• Chemical Name: Carbamic acid, [5-[(phenylamino)carbonyl]-1H-benzimidazol-2-yl]-, ethyl ester
• CAS No.: 89791-13-9
• Molecular Formula: C17H16N4O3
• Molecular Weight: 324.339
• Mol file: 89791-13-9.mol

Synonyms:

Chemical Property of Carbamic acid, [5-[(phenylamino)carbonyl]-1H-benzimidazol-2-yl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [5-[(phenylamino)carbonyl]-1H-benzimidazol-2-yl]-, ethyl ester

There total 6 articles about Carbamic acid, [5-[(phenylamino)carbonyl]-1H-benzimidazol-2-yl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

chloroformic acid ethyl ester (541-41-3) + S-Methylisothiourea sulfate (867-44-7,147895-43-0) + 5-phenylcarbamoyl-1,2-phenylenediamine (93-64-1) → (5-Phenylcarbamoyl-1H-benzoimidazol-2-yl)-carbamic acid ethyl ester (89791-13-9)

Guidance literature:

With sodium hydroxide; acetic acid; In ethanol; for 1h;

DOI:10.1021/jm00374a025

Reference yield:

3-nitro-4-acetamidobenzoic acid (1539-06-6) → (5-Phenylcarbamoyl-1H-benzoimidazol-2-yl)-carbamic acid ethyl ester (89791-13-9)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / benzene / 4 h / Heating

2: Et₃N / benzene / 2 h / Ambient temperature

3: 75 percent / 10percent aq. NaOH / ethanol / 1 h / Ambient temperature

4: 70 percent / hydrazine hydrate / Raney Ni / ethanol / 1 h / Heating

5: 72 percent / 25percent aq. NaOH, AcOH / ethanol / 1 h

With sodium hydroxide; thionyl chloride; hydrazine hydrate; acetic acid; triethylamine; nickel; In ethanol; benzene;

DOI:10.1021/jm00374a025

Reference yield:

3-nitro-4-acetylaminobenzoyl chloride (24170-23-8) → (5-Phenylcarbamoyl-1H-benzoimidazol-2-yl)-carbamic acid ethyl ester (89791-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / benzene / 2 h / Ambient temperature

2: 75 percent / 10percent aq. NaOH / ethanol / 1 h / Ambient temperature

3: 70 percent / hydrazine hydrate / Raney Ni / ethanol / 1 h / Heating

4: 72 percent / 25percent aq. NaOH, AcOH / ethanol / 1 h

With sodium hydroxide; hydrazine hydrate; acetic acid; triethylamine; nickel; In ethanol; benzene;

DOI:10.1021/jm00374a025

upstream raw materials:

chloroformic acid ethyl ester

S-Methylisothiourea sulfate

5-phenylcarbamoyl-1,2-phenylenediamine

3-nitro-4-acetamidobenzoic acid