3H-1,2,4-Triazol-3-one, 2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3 -dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-5-meth yl-, cis-

Base Information

Chemical Name:3H-1,2,4-Triazol-3-one, 2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3 -dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-5-meth yl-, cis-
CAS No.:89848-36-2
Molecular Formula:C37H41Cl2N7O4
Molecular Weight:718.683
Hs Code.:

3H-1,2,4-Triazol-3-one,
2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3
-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-5-meth
yl-, cis-

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Chemical Property of 3H-1,2,4-Triazol-3-one, 2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3 -dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-5-meth yl-, cis-

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Technology Process of 3H-1,2,4-Triazol-3-one, 2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3 -dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-5-meth yl-, cis-

There total 9 articles about 3H-1,2,4-Triazol-3-one, 2-butyl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3 -dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-5-meth yl-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 109-65-9
1-bromo-butane

: 89848-26-0
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

: 89848-36-2
2-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; for 14h;
DOI:10.1021/jm00373a015

Reference yield:

: 61397-61-3
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)methyl-(1,3-dioxolan-4-yl)]methyl methanesulfonate

: 89848-36-2
2-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) Me₂SO, 1 h, 2.) Me₂SO, 80 deg C, 5 h

2: 71 percent / NaOH / butan-1-ol / Heating

3: 54 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

4: 97 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

5: 82 percent / pyridine / CHCl₃ / 3 h

6: 98 percent / hydrazine hydrate / dioxane / 3 h / Heating

7: 44 percent / NaOAc / butan-1-ol

8: 70 percent / KOH / dimethylsulfoxide / 14 h

With thiophene; pyridine; potassium hydroxide; sodium hydroxide; hydrogen; sodium acetate; sodium hydride; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015

Reference yield:

: 67914-61-8
4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine

: 89848-36-2
2-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 97 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 82 percent / pyridine / CHCl₃ / 3 h

4: 98 percent / hydrazine hydrate / dioxane / 3 h / Heating

5: 44 percent / NaOAc / butan-1-ol

6: 70 percent / KOH / dimethylsulfoxide / 14 h

With thiophene; pyridine; potassium hydroxide; hydrogen; sodium acetate; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015