isoborneol

Base Information

• Chemical Name: isoborneol
• CAS No.: 10385-78-1
• Molecular Formula: C₁₀H₁₈O
• Molecular Weight: 154.252
• Mol file: 10385-78-1.mol

Synonyms:2-Bornanol(8CI); 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol;2-Hydroxy-1,7,7-trimethylnorbornane; Bingpian

Chemical Property of isoborneol

Chemical Property:

• Vapor Pressure: 0.0398mmHg at 25°C
• Melting Point: 213 °C
• Boiling Point: 212°Cat760mmHg
• PKA: 15.36±0.60(Predicted)
• Flash Point: 65.6°C
• PSA: 20.23000
• Density: 0.992g/cm³
• LogP: 2.19350

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isoborneol

There total 74 articles about isoborneol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

isobornyl acetate (28974-17-6) → isoborneol (124-76-5,464-43-7,464-45-9,507-70-0,6627-72-1,10334-13-1,10385-78-1,16725-71-6,24393-70-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; for 168h; Ambient temperature;

Reference yield: 96.0%

Carbonic acid 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester (1R,2R,4R)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester → isoborneol (124-76-5,464-43-7,464-45-9,507-70-0,6627-72-1,10334-13-1,10385-78-1,16725-71-6,24393-70-2)

Guidance literature:

In benzene; for 1h; Irradiation;

DOI:10.1021/jo00110a011

Reference yield: 90.0%

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (464-49-3,68546-28-1) → isoborneol (124-76-5,464-43-7,464-45-9,507-70-0,6627-72-1,10334-13-1,10385-78-1,16725-71-6,24393-70-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 25 ℃; for 22h;

DOI:10.1002/anie.202110849

upstream raw materials:

(1S)-camphor

isoborneol

Camphor

isobornyl butyrate

Downstream raw materials:

(+)-isobornyl acetate

Camphor

camphene

dl-camphene

Refernces

• 1、 Calderini, Elia,Drienovská, Ivana,Myrtollari, Kamela,Pressnig, Michaela,Sieber, Volker,Schwab, Helmut,Hofer, Michael,Kourist, Robert. "Simple Plug-In Synthetic Step for the Synthesis of (?)-Camphor from Renewable Starting Materials". . p. 2951 - 2956. Retrieved 2021/06/18.
• 2、 Baev, Dmitriy S.,Maksyutov, Rinat A.,Mordvinova, Ekaterina D.,Pyankov, Oleg V.,Salakhutdinov, Nariman F.,Shcherbakov, Dmitriy N.,Shcherbakova, Nadezhda S.,Sokolova, Anastasiya S.,Tolstikova, Tatyana G.,Yarovaya, Olga I.,Zaykovskaya, Anna V.,Zybkina, Anastasiya V.. "Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process". . . Retrieved 2020/09/09.