Technology Process of 2-Benzofurancarboxylic acid,
5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy-7-methyl
-, ethyl ester, (E)-
There total 9 articles about 2-Benzofurancarboxylic acid,
5-[(2-fluorophenyl)(hydroxyimino)methyl]-2,3-dihydro-6-hydroxy-7-methyl
-, ethyl ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; hydroxylamine hydrochloride;
for 4h;
Heating;
DOI:10.1021/jm00374a014
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. NaOH, 5percent sodium amalgam / 5 h
2: 50 percent / H2SO4 / Ambient temperature
3: 68 percent / AlCl3 / 1,2-dichloro-ethane / 0.17 h / 0 - 5 °C
4: 93 percent / BBr3 / CH2Cl2 / 0.25 h
5: 21 percent / NH2OH*HCl, pyridine / 4 h / Heating
With
pyridine; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; boron tribromide;
In
dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm00374a014
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 75 percent / BBr3 / CH2Cl2 / 1 h / 0 °C
2: K2CO3 / butan-2-one / 4 h / Heating
3: ethanolic KOH
4: aq. NaOH, 5percent sodium amalgam / 5 h
5: 50 percent / H2SO4 / Ambient temperature
6: 68 percent / AlCl3 / 1,2-dichloro-ethane / 0.17 h / 0 - 5 °C
7: 93 percent / BBr3 / CH2Cl2 / 0.25 h
8: 21 percent / NH2OH*HCl, pyridine / 4 h / Heating
With
pyridine; potassium hydroxide; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; boron tribromide; potassium carbonate;
In
dichloromethane; 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00374a014
