Chloromethyl phenyl sulfone

Base Information

• Chemical Name: Chloromethyl phenyl sulfone
• CAS No.: 7205-98-3
• Molecular Formula: C7H7ClO2S
• Molecular Weight: 190.65
• Hs Code.: 2904909090
• European Community (EC) Number: 230-581-8
• NSC Number: 41586
• UNII: QB5SR7NM49
• DSSTox Substance ID: DTXSID00222386
• Nikkaji Number: J129.166A
• Wikidata: Q63398186
• Mol file: 7205-98-3.mol

Synonyms:Chloromethyl phenyl sulfone;7205-98-3;((Chloromethyl)sulfonyl)benzene;chloromethylsulfonylbenzene;Phenyl chloromethyl sulfone;Benzene, [(chloromethyl)sulfonyl]-;CHLOROMethylphenYL SULFONE;((Chloromethyl)sulphonyl)benzene;Benzene, ((chloromethyl)sulfonyl)-;Sulfone, chloromethyl phenyl;QB5SR7NM49;EINECS 230-581-8;NSC-41586;AI3-09778;[(CHLOROMETHYL)SULPHONYL]BENZENE;1-(chloromethylsulfonyl)benzene;2-Chloromethylphenylsulfone;chloromethyl-phenylsulfone;chloromethanesulfonylbenzene;UNII-QB5SR7NM49;phenylsulfonylmethyl chloride;(chloromethylsulfonyl)benzene;Phenyl (chloromethyl) sulfone;SCHEMBL491272;(Phenylsulfonyl)methyl chloride;1-chloromethane-sulfonyl-benzene;DTXSID00222386;1-CHLOROMETHYLSULFONYLBENZENE;NSC41586;Chloromethyl phenyl sulfone, >=97%;MFCD00007551;NSC 41586;AKOS001286830;CS-W015862;BP-12033;FT-0623676;EN300-25369;D70212;J-520035;Q63398186;Z203881850

Chemical Property of Chloromethyl phenyl sulfone

Chemical Property:

• Vapor Pressure: 0.000197mmHg at 25°C
• Melting Point: 51-53 °C(lit.)
• Refractive Index: 1.544
• Boiling Point: 338.1 °C at 760 mmHg
• Flash Point: 158.3 °C
• PSA: 42.52000
• Density: 1.336 g/cm³
• LogP: 2.73740
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 189.9855283
• Heavy Atom Count: 11
• Complexity: 199

Purity/Quality:

98% ^*data from raw suppliers

Chloromethyl Phenyl Sulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)S(=O)(=O)CCl

Technology Process of Chloromethyl phenyl sulfone

There total 28 articles about Chloromethyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-Tolyl-chlorbrommethyl-sulfon (195371-23-4) → chloromethyl phenyl sulfone (7205-98-3)

Guidance literature:

With sodium tetrahydroborate; diphenyl diselenide; In tetrahydrofuran; ethanol; Ambient temperature;

DOI:10.1016/S0040-4039(97)01230-6

Reference yield: 98.0%

2-chloro-1-phenyl-2-(phenylsulfonyl)ethanone (38009-92-6) → chloromethyl phenyl sulfone (7205-98-3)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2006.11.129

Reference yield: 98.0%

N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine (565446-69-7) → chloromethyl phenyl sulfone (7205-98-3)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1016/S0968-0896(02)00651-X

upstream raw materials:

monoperoxyphthalic acid

phenylthiomethyl chloride

chloromethyl phenyl sulfoxide

ethanol

Downstream raw materials:

1-(chloro(phenylsulfonyl)methyl)cyclohexan-1-ol

5-Benzenesulfonylmethyl-7-methoxy-4-nitro-benzo[1,2,5]oxadiazole 1-oxide

7-Benzenesulfonylmethyl-5-methoxy-4-nitro-benzo[1,2,5]oxadiazole 1-oxide

1a,1b,2,7b-tetrahydro-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.8>naphthyridine

Refernces

• 1、 Geng, Jingjing,Song, Yanhong,Sun, Deli,Tong, Weiqi,Wu, Fan. "Ni-Catalyzed Asymmetric Reductive Alkenylation of α-Chlorosulfones with Vinyl Bromides". supporting information. p. 1807 - 1811. Retrieved 2022/03/27.
• 2、 Spitz, Cédric,Mathias, Fanny,Péchiné, Séverine,Doan, Tri Hanh Dung,Innocent, Jean,Pellissier, Sylvain,Di Giorgio, Carole,Crozet, Maxime D.,Janoir, Claire,Vanelle, Patrice. "2,4-Disubstituted 5-Nitroimidazoles Potent against Clostridium difficile". . p. 561 - 569. Retrieved 2019/02/13.