DAPSONE HYDROXYLAMINE

Base Information

• Chemical Name: DAPSONE HYDROXYLAMINE
• CAS No.: 32695-27-5
• Molecular Formula: C12H12 N2 O3 S
• Molecular Weight: 264.305
• Hs Code.: 2922199090
• Mol file: 32695-27-5.mol

Synonyms:Aniline,N-hydroxy-4,4'-sulfonyldi- (8CI); 4-(Hydroxyamino)-4'-aminodiphenyl sulfone;4-Amino-4'-(hydroxyamino)diphenyl sulfone; Dapsone hydroxylamine;N-Hydroxy-4,4'-sulfonyldi(aniline)

Chemical Property of DAPSONE HYDROXYLAMINE

Chemical Property:

• Vapor Pressure: 4.13E-12mmHg at 25°C
• Melting Point: 194°C dec.
• Boiling Point: 531.1°Cat760mmHg
• Flash Point: 275°C
• PSA: 100.80000
• Density: 1.464g/cm³
• LogP: 3.63770
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Dapsone Hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Dapsone A metabolite of Dapsone.

Technology Process of DAPSONE HYDROXYLAMINE

There total 2 articles about DAPSONE HYDROXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(4-nitrophenylsulfonyl)aniline (1948-92-1) → N-hydroxydapsone (32695-27-5)

Guidance literature:

With triethyl phosphite; platinum(IV) oxide; for 4h;

DOI:10.1016/j.bcp.2005.04.023

Reference yield:

dapsone (80-08-0) → N-hydroxydapsone (32695-27-5)

Guidance literature:

With GLUTATHIONE; human liver microsomes; NADPH; In water; at 37 ℃; for 0.166667h; Enzyme kinetics;

DOI:10.1016/0009-9236(95)90176-0

Reference yield:

N-hydroxydapsone (32695-27-5) → dapsone (80-08-0)

Guidance literature:

With 1,4-dihydronicotinamide adenine dinucleotide; human recombinant NADH cytochrome b₅ reductase; cytochrome b₅; In dimethyl sulfoxide; pH=7.4; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1124/jpet.104.072389

upstream raw materials:

4-(4-nitrophenylsulfonyl)aniline

dapsone

Downstream raw materials:

bis-(4-sulfanilyl-phenyl)-diazene-N-oxide

dapsone

bis-[4-(N-acetyl-sulfanilyl)-phenyl]-diazene-N-oxide