1948-92-1

Basic information

• Product Name: 4-NITRO-4'-AMINODIPHENYL SULFONE
• Synonyms: 4-(4-nitrobenzenesulfonyl)aniline;(4-Aminophenyl)4-nitrophenyl sulfone;4-(4-Nitrobenzenesulfonyl)phenylaMine;4-[(4-Nitrophenyl)sulfonyl]benzenaMine;NSC 27185;[4-(4-nitrophenyl)sulfonylphenyl]amine;{4-[(4-nitrophenyl)sulfonyl]phenyl}amine;Benzenamine, 4-((4-nitrophenyl)sulfonyl)-
• CAS NO: 1948-92-1
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.28
• Product Categories: Aromatics;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfones;Sulfur Compounds
• Mol File: 1948-92-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 155-157°C
• Boiling Point: 526.5°Cat760mmHg
• Flash Point: 272.2°C
• Appearance: /
• Density: 1.449g/cm³
• Vapor Pressure: 3.56E-11mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• CAS DataBase Reference: 4-NITRO-4'-AMINODIPHENYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-4'-AMINODIPHENYL SULFONE(1948-92-1)
• EPA Substance Registry System: 4-NITRO-4'-AMINODIPHENYL SULFONE(1948-92-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 1948-92-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

An intermediate in the synthesis of the Daspone metabolite

InChI:InChI=1/C12H10N2O4S/c13-9-1-5-11(6-2-9)19(17,18)12-7-3-10(4-8-12)14(15)16/h1-8H,13H2

Upstream product

• 101-59-7 4-amino-4'-nitrodiphenyl sulfide 
• 62-53-3 aniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 1576-44-9 N-nosylaniline 
• 1126-81-4 4-acetamidothiophenol 
• 100-00-5 4-chlorobenzonitrile 
• 15898-43-8 sodium 4-acetamidobenzenesulfinate 
• 7467-51-8 4-acetylamino-4'-nitrodiphenyl sulfide 
• 1775-37-7 N-[4-(4-Nitro-benzenesulfonyl)-phenyl]-acetamide 
• 1156-50-9 4-nitrophenyl sulfone 

Downstream Products

• 874509-08-7 [4-(4-nitro-benzenesulfonyl)-phenyl]-thiazol-2-yl-amine 
• 68997-77-3 N-furfurylidene-4-(4-nitro-benzenesulfonyl)-aniline 
• 412278-29-6 N-[4-(4-nitro-benzenesulfonyl)-phenyl]-succinamic acid 
• 68997-76-2 4-(4-nitro-benzenesulfonyl)-N-(3-nitro-benzyliden)-aniline 
• 69039-57-2 N-(4-methoxy-benzylidene)-4-(4-nitro-benzenesulfonyl)-aniline 
• 51688-36-9 hexanoic acid-[4-(4-nitro-benzenesulfonyl)-anilide] 
• 60515-98-2 N-(4-diethylamino-benzylidene)-4-(4-nitro-benzenesulfonyl)-aniline 
• 51688-34-7 butyric acid-[4-(4-nitro-benzenesulfonyl)-anilide] 
• 850856-68-7 isovaleric acid-[4-(4-nitro-benzenesulfonyl)-anilide] 
• 874529-28-9 2-[4-(4-nitro-benzenesulfonyl)-anilino]-ethanol 
• 60515-97-1 C₃₂H₂₂N₄O₈S₂ 
• 60515-80-2 4-(N-Butylamino-acetylamino)-4'-nitro-diphenylsulfon 
• 60515-96-0 N,N'-Bis-[4-(4-nitro-benzenesulfonyl)-phenyl]-formamidine 
• 60515-79-9 [4-(4-nitro-benzenesulfonyl)-phenyl]-carbamic acid methyl ester 

Relevant articles and documents

Efficient Liquid-Assisted Grinding Selective Aqueous Oxidation of Sulfides Using Supported Heteropolyacid Catalysts

The present work reports the preparation of 40MoAl200 and its full characterization using a number of analytical techniques (XRD, TEM, TGA, BET, EDX). Liquid-assisted ball milling proved to be a key tool to achieve both the best efficiency of 40MoAl200 as a novel Keggin type catalyst in the selective sulfoxidation reaction and also for succeeding in its effective recovery and reuse. In addition, the liquid assisted grinding process was studied in detail evaluating the influence of different parameters such as frequency of rotation (rpm), number and size of the stainless steel balls used and reaction time. The use of aqueous hydrogen peroxide is essential as water proved to exert a crucial role to improve both yields and selectivity towards sulfoxide formation. The procedure was representatively extended to a number of substrates with the possibility to extend the scope of the system to produce sulfoxides in high yields (up to 95 %) and satisfactory selectivities (up to 80 %). The catalyst proved to be recoverable and reusable under the optimized reaction conditions.

Studies on 2,3,N,N'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents

A series of new 4,4'-diaminodiphenylsulfones substituted at 2 and 3 position and also at primary amino group of the phenyl rings have been synthesised and evaluated for their antimalarial activity against Plasmodium berghei infection in mice. Some of these compounds were active and showed complete inhibition of parasitaemia which included 7a1-7a4, 7b3, 7b4 and 16a at 1 mg/kg i.p. for 4 days and 16a, at 0.3 mg/kg for 4 days. Some compounds tested for their synthetase inhibitory action in cell-free system isolated from P. berghei (7b1, 7b2 and 8b2) were found to be more active than diaminodiphenylsulphone. The difference in order of activity between these in vivo and in vitro tests may be due to differences in their pharmacokinetic properties.

Process for the partial reduction of polynitrated diaryl compounds

Polynitrated diaryl compounds of the formula given in the description are reduced with 1-2 mols of sulphides, or compounds which donate sulphide ions, per mol of nitro group in the presence of 0.5-10 mols of ammonia per mol of starting compound at 30°-110° C. to give nitroamino-diaryl compounds, for example 4,4'-dinitro-dibenzyl-2,2'-disulphonic acid is reduced to 4-nitro-4'-amino-stilbene-2,2'-disulphonic acid.