1-methyl-2-phenyl-4(1H)-quinolinone

Base Information

• Chemical Name: 1-methyl-2-phenyl-4(1H)-quinolinone
• CAS No.: 17182-60-4
• Molecular Formula: C16H13 N O
• Molecular Weight: 235.285
• DSSTox Substance ID: DTXSID50169171
• Nikkaji Number: J548.598C
• Wikidata: Q83038824
• Metabolomics Workbench ID: 130005
• ChEMBL ID: CHEMBL277048
• Mol file: 17182-60-4.mol

Synonyms:4(1H)-Quinolone,1-methyl-2-phenyl- (7CI,8CI); 1-Methyl-2-phenyl-4-quinolinone;1-Methyl-2-phenyl-4-quinolone

Chemical Property of 1-methyl-2-phenyl-4(1H)-quinolinone

Chemical Property:

• Vapor Pressure: 5.85E-06mmHg at 25°C
• Melting Point: 136 °C
• Boiling Point: 379.4°Cat760mmHg
• PKA: 1.74±0.70(Predicted)
• Flash Point: 148°C
• PSA: 22.00000
• Density: 1.18g/cm³
• LogP: 3.20550
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 354

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C(=O)C=C1C3=CC=CC=C3

Technology Process of 1-methyl-2-phenyl-4(1H)-quinolinone

There total 35 articles about 1-methyl-2-phenyl-4(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-[2-(N-methyl)amino]phenyl-3-phenyl-2-propyn-1-one → N-methyl-2-phenylquinolin-4(1H)-one (17182-60-4)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; regioselective reaction;

DOI:10.1002/bkcs.12239

Reference yield: 88.0%

C16H14ClNO → N-methyl-2-phenylquinolin-4(1H)-one (17182-60-4)

Guidance literature:

With basic alumina supported anhydrous K₂CO₃; at 90 ℃; for 12h; regiospecific reaction; Green chemistry;

DOI:10.1039/c5ra21421a

Reference yield: 85.0%

C16H14BrNO (1516898-17-1) → N-methyl-2-phenylquinolin-4(1H)-one (17182-60-4)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane;

DOI:10.5012/bkcs.2013.34.10.3117

upstream raw materials:

4-methoxy-2-phenyl-quinoline

methyl iodide

4-methoxy-1-methyl-2-phenyl-quinolinium; iodide

2-phenyl-1H-quinolin-4-one

Downstream raw materials:

3-iodo-1-methyl-2-phenylquinolin-4(1H)-one