2-PHENYL-1H-QUINOLIN-4-ONE

Base Information

• Chemical Name: 2-PHENYL-1H-QUINOLIN-4-ONE
• CAS No.: 14802-18-7
• Molecular Formula: C15H11 N O
• Molecular Weight: 221.258
• Mol file: 14802-18-7.mol

Synonyms:4(1H)-Quinolone,2-phenyl- (6CI,7CI,8CI); 1,4-Dihydro-2-phenyl-4-oxoquinoline; 1-Azaflavone;2-Phenyl-1H-quinolin-4-one; 2-Phenyl-4(1H)-quinolinone;2-Phenyl-4-oxohydroquinoline; 2-Phenyl-4-quinolinone; 2-Phenyl-4-quinolone; YT1

Chemical Property of 2-PHENYL-1H-QUINOLIN-4-ONE

Chemical Property:

• Melting Point: 256-258 °C
• Boiling Point: 385.3°Cat760mmHg
• PKA: 1.49±0.70(Predicted)
• Flash Point: 158.3°C
• PSA: 32.86000
• Density: 1.2g/cm³
• LogP: 3.19510

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-1H-QUINOLIN-4-ONE

There total 105 articles about 2-PHENYL-1H-QUINOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-<2-(Benzylamino)phenyl>ethanon (104014-46-2) → 2-phenyl-1H-quinolin-4-one (14802-18-7)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; In dimethyl sulfoxide; at 20 - 80 ℃; for 6h; Reagent/catalyst; Solvent; Temperature; Time;

DOI:10.1021/acs.orglett.5b00248

Reference yield: 96.0%

2'-acetylbenzanilide (6011-26-3) → 2-phenyl-1H-quinolin-4-one (14802-18-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 110 ℃; for 1h;

DOI:10.1021/jo701384n

Reference yield: 96.0%

1-(2-Aminophenyl)-3-phenyl-2-propyn-1-one (124857-13-2) → 2-phenyl-1H-quinolin-4-one (14802-18-7)

Guidance literature:

With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In acetonitrile; at 20 ℃; for 24h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1002/ejoc.201402224

upstream raw materials:

2-phenyl-2,3-dihydro-1H-quinolin-4-one

1,5-diphenyl-2,3-pyrrolinedione

ethanol

2'-amino-α-azidochalcone

Downstream raw materials:

N-methyl-2-phenylquinolin-4(1H)-one

2-(Benzoylamino)benzoic Acid

(benzo[c]isoxazol-3-yl)(phenyl)methanone

2-phenyl-4H-3,1-benzoxazin-4-one