Pyridine-2,5-dicarbohydrazide

Base Information

• Chemical Name: Pyridine-2,5-dicarbohydrazide
• CAS No.: 6011-55-8
• Molecular Formula: C7H9N5O2
• Molecular Weight: 195.1787
• NSC Number: 64856
• DSSTox Substance ID: DTXSID40289832
• Nikkaji Number: J716.031C
• Wikidata: Q82027319
• Mol file: 6011-55-8.mol

Synonyms:pyridine-2,5-dicarbohydrazide;6011-55-8;2,5-pyridinedicarbohydrazide;Isocinchomeronic acid dihydrazide;2, dihydrazide;Isocinchomeronic dihydrazide;NCIOpen2_000002;SCHEMBL9180143;DTXSID40289832;NSC64856;NSC-64856;AKOS006229111;2,5-Pyridinedicarboxylic acid dihydrazide;AQ-776/42801110

Chemical Property of Pyridine-2,5-dicarbohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 123.13000
• Density: 1.417g/cm³
• LogP: 0.47100
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 195.07562455
• Heavy Atom Count: 14
• Complexity: 232

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1C(=O)NN)C(=O)NN

Technology Process of Pyridine-2,5-dicarbohydrazide

There total 6 articles about Pyridine-2,5-dicarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyridine-2,5-dicarboxylic acid dichloride (5620-35-9) → 2,5-pyridinedicarboxylic dihydrazide (6011-55-8)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.3184/174751914X13896291543361

Reference yield:

dimethyl 2,5-pyridine dicarboxylate (881-86-7) → 2,5-pyridinedicarboxylic dihydrazide (6011-55-8)

Guidance literature:

With ethanol; hydrazine hydrate;

Reference yield:

Pyridine-2,5-dicarboxylic acid (100-26-5) → 2,5-pyridinedicarboxylic dihydrazide (6011-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated sulfuric acid

2: alcohol; hydrazine hydrate (1 part )

With ethanol; sulfuric acid; hydrazine hydrate;

upstream raw materials:

dimethyl 2,5-pyridine dicarboxylate

ethyl 2,5-pyridinedicarboxylate

Pyridine-2,5-dicarboxylic acid

pyridine-2,5-dicarboxylic acid dichloride

Downstream raw materials:

pyridine-2,5-dicarboxylic acid bis-benzylidenehydrazide

C₂₁H₁₅Br₂N₅O₄

C₂₁H₁₇N₅O₄

C₃₃H₂₃N₇O₂

Refernces

• 1、 Barlin, Gordon B.. "Heterocyclic Amplifiers of Phleomycin. VIII Mono- and Bis-(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines and Mono(5'-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines". . p. 1491 - 1497. Retrieved 2007/10/02.