Welcome to LookChem.com Sign In|Join Free

CAS

  • or

881-86-7

Post Buying Request

881-86-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

881-86-7 Usage

Uses

Different sources of media describe the Uses of 881-86-7 differently. You can refer to the following data:
1. Intermediate for the synthesis of potent antitumor agents.
2. It is the intermediate in the synthesis of potent antitumor agents.

General Description

Dimethyl 2,5-pyridine dicarboxylate can be prepared from 2,5-pyridinedicarboxylic acid.

Check Digit Verification of cas no

The CAS Registry Mumber 881-86-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,8 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 881-86:
(5*8)+(4*8)+(3*1)+(2*8)+(1*6)=97
97 % 10 = 7
So 881-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO4/c1-13-8(11)6-3-4-7(10-5-6)9(12)14-2/h3-5H,1-2H3

881-86-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A17250)  Dimethyl pyridine-2,5-dicarboxylate, 98+%   

  • 881-86-7

  • 1g

  • 207.0CNY

  • Detail
  • Alfa Aesar

  • (A17250)  Dimethyl pyridine-2,5-dicarboxylate, 98+%   

  • 881-86-7

  • 5g

  • 331.0CNY

  • Detail
  • Alfa Aesar

  • (A17250)  Dimethyl pyridine-2,5-dicarboxylate, 98+%   

  • 881-86-7

  • 25g

  • 1362.0CNY

  • Detail
  • Alfa Aesar

  • (A17250)  Dimethyl pyridine-2,5-dicarboxylate, 98+%   

  • 881-86-7

  • 100g

  • 4937.0CNY

  • Detail
  • Aldrich

  • (540234)  Dimethyl2,5-pyridinedicarboxylate  97%

  • 881-86-7

  • 540234-25G

  • 1,084.59CNY

  • Detail
  • Aldrich

  • (540234)  Dimethyl2,5-pyridinedicarboxylate  97%

  • 881-86-7

  • 540234-25G

  • 1,084.59CNY

  • Detail
  • Aldrich

  • (540234)  Dimethyl2,5-pyridinedicarboxylate  97%

  • 881-86-7

  • 540234-25G

  • 1,084.59CNY

  • Detail
  • Aldrich

  • (540234)  Dimethyl2,5-pyridinedicarboxylate  97%

  • 881-86-7

  • 540234-25G

  • 1,084.59CNY

  • Detail

881-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Dimethyl pyridine-2,5-dicarboxylate

1.2 Other means of identification

Product number -
Other names DIMETHYL PYRIDINE-2,5-DICARBOXYLATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:881-86-7 SDS

881-86-7Relevant articles and documents

Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis

Ashbrook, Chloe,Carnell, Andrew J.,Goulding, Ellie,Hatton, Harry,Johnson, James R.,Kershaw, Neil M.,McCue, Hannah V.,Rigden, Daniel J.,Ward, Lucy C.

supporting information, (2022/02/21)

Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic acids are generally better substrates than monocarboxylic acids, although some substituents are able to compensate for the absence of a second acid group. For dicarboxylic acids, the second methylation shows strong pH dependency with an optimum at pH 5.5–6. Potential for application in industrial biotechnology was demonstrated in a cascade for the production of a bioplastics precursor (FDME) from bioderived 5-hydroxymethylfurfural (HMF).

Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids

Zuin Fantoni, Nicolò,McGorman, Bríonna,Molphy, Zara,Singleton, Daniel,Walsh, Sarah,El-Sagheer, Afaf H.,McKee, Vickie,Brown, Tom,Kellett, Andrew

, p. 3563 - 3574 (2020/10/02)

In the field of nucleic acid therapy there is major interest in the development of libraries of DNA-reactive small molecules which are tethered to vectors that recognize and bind specific genes. This approach mimics enzymatic gene editors, such as ZFNs, TALENs and CRISPR-Cas, but overcomes the limitations imposed by the delivery of a large protein endonuclease which is required for DNA cleavage. Here, we introduce a chemistry-based DNA-cleavage system comprising an artificial metallo-nuclease (AMN) that oxidatively cuts DNA, and a triplex-forming oligonucleotide (TFO) that sequence-specifically recognises duplex DNA. The AMN-TFO hybrids coordinate CuII ions to form chimeric catalytic complexes that are programmable – based on the TFO sequence employed – to bind and cut specific DNA sequences. Use of the alkyne-azide cycloaddition click reaction allows scalable and high-throughput generation of hybrid libraries that can be tuned for specific reactivity and gene-of-interest knockout. As a first approach, we demonstrate targeted cleavage of purine-rich sequences, optimisation of the hybrid system to enhance stability, and discrimination between target and off-target sequences. Our results highlight the potential of this approach where the cutting unit, which mimics the endonuclease cleavage machinery, is directly bound to a TFO guide by click chemistry.

New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action

Ohui, Kateryna,Afanasenko, Eleonora,Bacher, Felix,Ting, Rachel Lim Xue,Zafar, Ayesha,Blanco-Cabra, Núria,Torrents, Eduard,D?m?t?r, Orsolya,May, Nóra V.,Darvasiova, Denisa,Enyedy, éva A.,Popovi?-Bijeli?, Ana,Reynisson, Jóhannes,Rapta, Peter,Babak, Maria V.,Pastorin, Giorgia,Arion, Vladimir B.

supporting information, p. 512 - 530 (2019/01/04)

Six morpholine-(iso)thiosemicarbazone hybrids HL1-HL6 and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Cu(II) complexes [Cu(L1-6)Cl] (1-6) formed weak dimeric associates in the solid state, which did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu(II) complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition, complexes 2-5 were found to specifically inhibit the growth of Gram-positive bacteria Staphylococcus aureus with MIC50 values at 2-5 μg/mL. Insights into the processes controlling intracellular accumulation and mechanism of action were investigated for 2 and 5, including the role of ribonucleotide reductase (RNR) inhibition, endoplasmic reticulum stress induction, and regulation of other cancer signaling pathways. Their ability to moderately inhibit R2 RNR protein in the presence of dithiothreitol is likely related to Fe chelating properties of the proligands liberated upon reduction.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 881-86-7