4-Fluoro-2-(2-fluorobenzimidazo(1,2-c)quinazolin-6-yl)aniline

Base Information

• Chemical Name: 4-Fluoro-2-(2-fluorobenzimidazo(1,2-c)quinazolin-6-yl)aniline
• CAS No.: 10173-67-8
• Molecular Formula: C20H12 F2 N4
• Molecular Weight: 346.339
• NSC Number: 128747
• UNII: A86L6EMT8G
• DSSTox Substance ID: DTXSID20144152
• Nikkaji Number: J3.535.638J
• Wikidata: Q83008249
• Mol file: 10173-67-8.mol

Synonyms:10173-67-8;4-Fluoro-2-(2-fluorobenzimidazo(1,2-c)quinazolin-6-yl)aniline;NSC128747;NSC 128747;NSC-128747;4-Fluoro-2-(2-fluorobenzimidazo[1,2-c]quinazolin-6-yl)aniline;4-fluoro-2-(2-fluorobenzimidazolo[1,2-c]quinazolin-6-yl)aniline;A86L6EMT8G;DTXSID20144152;4-Fluoro-2-(2-fluorobenzimidazo[1,2-c]quinazolin-6-yl)benzenamine;4-Fluoro-2-(2-fluorobenzimidazo[1,2-c]quinazolin-6-yl)phenylamine;4-Fluoro-2-(2-fluorobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)aniline;Benzenamine, 4-fluoro-2-(2-fluorobenzimidazo[1,2-c]quinazolin-6-yl)-;Benzimidazo[1,2-c]quinazoline, 6-(2-amino-5-fluorophenyl)-2-fluoro-

Chemical Property of 4-Fluoro-2-(2-fluorobenzimidazo(1,2-c)quinazolin-6-yl)aniline

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.47g/cm³
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 346.10300272
• Heavy Atom Count: 26
• Complexity: 520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=C3N2C(=NC4=C3C=C(C=C4)F)C5=C(C=CC(=C5)F)N

Technology Process of 4-Fluoro-2-(2-fluorobenzimidazo(1,2-c)quinazolin-6-yl)aniline

There total 3 articles about 4-Fluoro-2-(2-fluorobenzimidazo(1,2-c)quinazolin-6-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

2-(2-bromo-5-fluorophenyl)-1H-benzo[d]imidazole (1097793-35-5) + 2-amino-5-fluoro benzaldehyde (146829-56-3) → 4-fluoro-2-(2-fluorobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)aniline (10173-67-8)

Guidance literature:

2-(2-bromo-5-fluorophenyl)-1H-benzo[d]imidazole; 2-amino-5-fluoro benzaldehyde; With copper; caesium carbonate; L-proline; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

2-amino-5-fluorobenzoic acid (446-08-2) + 1,2-diamino-benzene (95-54-5) → 4-fluoro-2-(2-fluorobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)aniline (10173-67-8)

Guidance literature:

With polyphosphoric acid; at 140 ℃;

DOI:10.1016/j.bioorg.2019.103266

Reference yield:

→ 4-fluoro-2-(2-fluorobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)aniline (10173-67-8)

Guidance literature:

o-Phenylendiamin, 5-Fluor-2-amino-benzoesaeure, Polyphosphorsaeure (250grad, 2h);

upstream raw materials:

2-amino-5-fluorobenzoic acid

1,2-diamino-benzene

2-(2-bromo-5-fluorophenyl)-1H-benzo[d]imidazole

2-amino-5-fluoro benzaldehyde

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