2-AMINO-5-FLUOROBENZALDEHYDE

Base Information

• Chemical Name: 2-AMINO-5-FLUOROBENZALDEHYDE
• CAS No.: 146829-56-3
• Molecular Formula: C7H6FNO
• Molecular Weight: 139.129
• Mol file: 146829-56-3.mol

Synonyms:2-AMINO-5-FLUOROBENZALDEHYDE;

Chemical Property of 2-AMINO-5-FLUOROBENZALDEHYDE

Chemical Property:

• Boiling Point: 260℃
• Flash Point: 111℃
• PSA: 43.09000
• Density: 1.293
• LogP: 1.80160
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-5-fluorobenzaldehyde is a building block used in various synthetic preparations. It was used as a reactant in the stereoselective preparation of aryltetrahydroquinolines via gold-phosphine catalyzed heterocyclization of aminobenzaldehyde with alkynes.

Technology Process of 2-AMINO-5-FLUOROBENZALDEHYDE

There total 5 articles about 2-AMINO-5-FLUOROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-fluoro-2-nitrobenzaldehyde (395-81-3) → 2-amino-5-fluoro benzaldehyde (146829-56-3)

Guidance literature:

With hydrogenchloride; iron; acetic acid; In ethanol; water; at 65 ℃; for 5h;

Reference yield: 85.0%

(2-amino-5-fluorophenyl)methanol (748805-85-8) → 2-amino-5-fluoro benzaldehyde (146829-56-3)

Guidance literature:

With dmap; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; In acetonitrile; at 20 ℃; for 6h; chemoselective reaction;

DOI:10.1002/open.201402082

Reference yield: 44.5%

2-bromo-5-fluorobenzaldehyde (94569-84-3) → 2-amino-5-fluoro benzaldehyde (146829-56-3)

Guidance literature:

With sodium azide; sodium L-ascorbate; rac-Pro-OH; In water; dimethyl sulfoxide; at 70 ℃;

DOI:10.1111/cbdd.12460

upstream raw materials:

5-fluoro-2-nitrobenzaldehyde

(2-amino-5-fluorophenyl)methanol

2-amino-5-fluorobenzoic acid

2-bromo-5-fluorobenzaldehyde

Downstream raw materials:

C₁₀H₁₀FNO₂

(S)-6-fluoro-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 Jin, Xiao-Yan,Chen, Hao,Li, Dong-Dong,Li, A-Liang,Wang, Wen-Yan,Gu, Wen. "Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors". . p. 955 - 972. Retrieved 2019.
• 2、 Meng, Xiang-He,Wu, Dan-Ni,Zhang, Yu-Jia,Zhao, Yu-Long. "PPTS-Catalyzed Bicyclization Reaction of 2-Isocyanobenzaldehydes with Various Amines: Synthesis of Diverse Fused Quinazolines". supporting information. p. 1923 - 1929. Retrieved 2021/02/26.
• 3、 Laraia, Luca,Olsen, Asger Hegelund,Whitmarsh-Everiss, Thomas. "Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol-Inspired Compound Collection". supporting information. p. 26755 - 26761. Retrieved 2021/11/17.