Morphine hydrochloride

Base Information

• Chemical Name: Morphine hydrochloride
• CAS No.: 52-26-6
• Molecular Formula: C17H19 N O3 . Cl H
• Molecular Weight: 321.804
• European Community (EC) Number: 200-136-2
• UNII: J28GE0ROVX
• DSSTox Substance ID: DTXSID10110023,DTXSID501045894
• Wikidata: Q27124243
• NCI Thesaurus Code: C83973
• ChEMBL ID: CHEMBL556578
• Mol file: 52-26-6.mol

Synonyms:Chloride, Morphine;Contin, MS;Duramorph;Morphia;Morphine;Morphine Chloride;Morphine Sulfate;Morphine Sulfate (2:1), Anhydrous;Morphine Sulfate (2:1), Pentahydrate;MS Contin;Oramorph SR;SDZ 202 250;SDZ 202-250;SDZ 202250;SDZ202 250;SDZ202-250;SDZ202250;Sulfate, Morphine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Morphine hydrochloride

Chemical Property:

• Vapor Pressure: 7.06E-10mmHg at 25°C
• Melting Point: about 200° (dec)
• Boiling Point: 476.2°Cat760mmHg
• Flash Point: 241.8°C
• PSA: 188.84000
• Density: g/cm³
• LogP: 2.70000
• Storage Temp.: −20°C
• Solubility.: Soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in toluene.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 321.1131712
• Heavy Atom Count: 22
• Complexity: 494

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-24-33-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.Cl
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.Cl
• Recent ClinicalTrials: Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled
• Recent EU Clinical Trials: Intrathecal morphine for minimally invasive direct coronary artery bypass surgery: a multicentre, double blind, prospective randomized placebo-controlled trial
• Recent NIPH Clinical Trials: Comparative test of morphine hydrochloride internal solution and hydromorphone hydrochloride tablets on idiopathic dyspnea
• Uses: Opioid receptor agonist; analgesic.

Technology Process of Morphine hydrochloride

There total 1 articles about Morphine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

morphine-N-oxide hydrochloride (1234788-64-7) → morphine hydrochloride (52-26-6) + Normorphine hydrochloride (3372-02-9)

Guidance literature:

With iron; In isopropyl alcohol; at 40 ℃; Inert atmosphere;

DOI:10.1021/jo1008492

Reference yield: 95.0%

morphine hydrochloride (52-26-6) + benzoyl chloride (98-88-4) → 7,8-didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol 3-benzoate (105092-16-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 74h;

DOI:10.1055/s-2000-6413

Reference yield: 93.0%

morphine hydrochloride (52-26-6) → MORPHIN (57-27-2)

Guidance literature:

With sodium carbonate; In water;

DOI:10.1016/j.ijpharm.2015.04.071

upstream raw materials:

morphine-N-oxide hydrochloride

Downstream raw materials:

4,5-epoxy-6-formyloxy-17-methyl-morphin-7-en-3-ol

hydromorphone

dihydromorphine

3-O-benzylmorphine

Refernces