Carbamic acid, [4-[(phenylmethyl)amino]butyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [4-[(phenylmethyl)amino]butyl]-, 1,1-dimethylethyl ester
• CAS No.: 90914-09-3
• Molecular Formula: C16H26N2O2
• Molecular Weight: 278.395
• Mol file: 90914-09-3.mol

Synonyms:tert-butyl [4-(benzylamino)butyl]carbamate;N-[N-(tert-Butoxycarbonyl)-4-aminobutyl]benzylamine;

Chemical Property of Carbamic acid, [4-[(phenylmethyl)amino]butyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 406.7±28.0 °C(Predicted)
• PSA: 50.36000
• Density: 1.010±0.06 g/cm3(Predicted)
• LogP: 3.86290

Purity/Quality:

97% ^*data from raw suppliers

Boc-DAB-Bzl*HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [4-[(phenylmethyl)amino]butyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [4-[(phenylmethyl)amino]butyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + benzaldehyde (100-52-7) → N(1)-benzyl-N(4)-(tert-butyloxycarbonyl)-1,4-diaminobutane (90914-09-3)

Guidance literature:

1-amino-4-[(tert-butyloxycarbonyl)amino]butane; benzaldehyde; In methanol; at 23 ℃; for 0.75h;

With sodium tetrahydroborate; In methanol; at 23 ℃; for 17h;

DOI:10.1002/hlca.200490129

Reference yield: 92.0%

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + N-(4-aminobutyl)(phenylmethyl)amine (29867-04-7) → N(1)-benzyl-N(4)-(tert-butyloxycarbonyl)-1,4-diaminobutane (90914-09-3)

Guidance literature:

In tetrahydrofuran; 0 deg C -> RT;

DOI:10.1021/jo00190a028

Reference yield:

[4-(benzylideneamino)butyl]carbamic acid tert-butyl ester (378785-51-4) → N(1)-benzyl-N(4)-(tert-butyloxycarbonyl)-1,4-diaminobutane (90914-09-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; Heating;

DOI:10.1023/A:1011988317683

upstream raw materials:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

N-(4-aminobutyl)(phenylmethyl)amine

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

benzaldehyde

Downstream raw materials:

tert-butyl {4-{[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl][(2E)-3-phenylprop-2-enoyl]amino}butyl}carbamate

C₂₆H₃₄N₂O₆

N₁,N₅-di-boc-spermidine

N⁽¹⁾-(p-aminobenzoyl)-N⁽⁴⁾,N⁽⁸⁾-di-(tert-butyloxycarbonyl)-1,8-diamino-4-azaoctane