ethyl 2-methyl-2-phenylcyclopropanecarboxylate

Base Information

• Chemical Name: ethyl 2-methyl-2-phenylcyclopropanecarboxylate
• CAS No.: 36122-28-8
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Mol file: 36122-28-8.mol

Synonyms:

Chemical Property of ethyl 2-methyl-2-phenylcyclopropanecarboxylate

Chemical Property:

• Vapor Pressure: 0.00641mmHg at 25°C
• Boiling Point: 271.6°Cat760mmHg
• Flash Point: 110°C
• Density: 1.075g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-methyl-2-phenylcyclopropanecarboxylate

There total 26 articles about ethyl 2-methyl-2-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diazoacetic acid ethyl ester (623-73-4) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → ethyl 2-methyl-2-phenylcyclopropane-1-carboxylate (36122-28-8)

Guidance literature:

With trans-NN'-ethylenebis(salicylideneiminato)bis(triphenylphosphine)ruthenium(II); (R)-1-(benzylsulfinyl)-4-methylbenzene; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1002/anie.200460887

Reference yield: 80.0%

diazoacetic acid ethyl ester (623-73-4) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → ethyl cis-2-methyl-2-phenylcyclopropanecarboxylate (27070-05-9,27070-06-0,36122-28-8) + trans-ethyl 2-methyl-2-phenylcyclopropanecarboxylate (27070-05-9,27070-06-0,36122-28-8)

Guidance literature:

With C₇₇H₅₅Cl₄FeN₈O₅; In toluene; at 25 ℃; for 0.0833333h; Temperature; diastereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201602289

Reference yield: 80.0%

diazoacetic acid ethyl ester (623-73-4) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → ethyl cis-2-methyl-2-phenylcyclopropanecarboxylate (27070-05-9,27070-06-0,36122-28-8) + trans-ethyl 2-methyl-2-phenylcyclopropanecarboxylate (27070-05-9,27070-06-0,36122-28-8)

Guidance literature:

With C₇₇H₅₅Cl₄FeN₈O₅; In toluene; at 25 ℃; for 0.0833333h; Temperature; diastereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201602289

upstream raw materials:

diazoacetic acid ethyl ester

isopropenylbenzene

4-vinylbenzyl chloride

1-phenylpropene

Downstream raw materials:

trans-2-methyl-2-phenylcyclopropanecarboxylic acid

2-methyl-2-phenylcyclopropanecarboxylic acid

5-methyl-5-phenyl-dihydro-furan-2-one

(1S*,2S*)-2-methyl-2-phenylcyclopropane-1-carboxamide