4-METHOXYPHENYL (E)-3-(4-METHOXYPHENOXY)-2-PROPENOATE

Base Information

• Chemical Name: 4-METHOXYPHENYL (E)-3-(4-METHOXYPHENOXY)-2-PROPENOATE
• CAS No.: 323208-04-4
• Molecular Formula: C₁₇H₁₆O₅
• Molecular Weight: 300.311
• Mol file: 323208-04-4.mol

Synonyms:

Chemical Property of 4-METHOXYPHENYL (E)-3-(4-METHOXYPHENOXY)-2-PROPENOATE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-METHOXYPHENYL (E)-3-(4-METHOXYPHENOXY)-2-PROPENOATE

There total 2 articles about 4-METHOXYPHENYL (E)-3-(4-METHOXYPHENOXY)-2-PROPENOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methoxy-phenol (150-76-5) + Propiolic acid (471-25-0) → 4-methoxyphenyl (E)-3-(4-methoxyphenoxy)acrylate (323208-04-4)

Guidance literature:

With dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In chloroform; at 0 - 18 ℃; for 16h;

DOI:10.1021/acs.joc.0c02011

Reference yield: 35.0%

4-methoxy-phenol (150-76-5) + Propiolic acid (471-25-0) → 4-methoxyphenyl propynoate (90920-97-1) + 4-methoxyphenyl (E)-3-(4-methoxyphenoxy)acrylate (323208-04-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1080/00397910008087068

Reference yield: 93.0%

N-methoxybenzamide (2446-51-7) + 4-methoxyphenyl (E)-3-(4-methoxyphenoxy)acrylate (323208-04-4) → 4-methoxyphenyl 2-(2-methoxy-3-oxoisoindolin-1-yl)acetate

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; In acetone; at 60 ℃; for 6h; regioselective reaction; Schlenk technique; Sealed tube;

DOI:10.1039/d1ob01792f

upstream raw materials:

4-methoxy-phenol

Propiolic acid