(Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid

Base Information

Chemical Name:(Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid
CAS No.:143651-44-9
Molecular Formula:C₁₆H₁₁NO₄
Molecular Weight:281.268
Hs Code.:
Nikkaji Number:J506.479A
Wikidata:Q76386674
Mol file:143651-44-9.mol

Synonyms:3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid;TA 3037A;TA-3037A

Suppliers and Price of (Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid

Chemical Property:

Vapor Pressure:8.37E-12mmHg at 25°C
Boiling Point:523.9°Cat760mmHg
Flash Point:270.6°C
PSA：83.30000
Density:1.405g/cm³
LogP:1.92920
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:281.06880783
Heavy Atom Count:21
Complexity:453

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C=C2C(=O)OC3=CC=CC(=C3N2)C(=O)O
Isomeric SMILES:C1=CC=C(C=C1)/C=C\2/C(=O)OC3=CC=CC(=C3N2)C(=O)O

Technology Process of (Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid

There total 4 articles about (Z)-3,4-Dihydro-2-oxo-3-(phenylmethylene)-2H-1,4-benzoxazine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 186417-06-1
diphenylmethyl (Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylate

: 143651-44-9
(Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid

Guidance literature:: With trifluoroacetic acid; for 0.333333h; Ambient temperature;

Reference yield:

: 6362-58-9
methyl phenylpyruvate

: 143651-44-9
(Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / para-toluenesulfonic acid monohydrate / toluene / 24 h / 110 °C

2: 64 percent / trifluoroacetic acid / 0.33 h / Ambient temperature

With toluene-4-sulfonic acid; trifluoroacetic acid; In toluene;

Reference yield:

: 186417-05-0
diphenylmethyl 2-amino-3-hydroxybenzoate

: 143651-44-9
(Z)-3-benzylidene-3,4-dihydro-2-oxo-2H-1,4-benzoxazine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / para-toluenesulfonic acid monohydrate / toluene / 24 h / 110 °C

2: 64 percent / trifluoroacetic acid / 0.33 h / Ambient temperature

With toluene-4-sulfonic acid; trifluoroacetic acid; In toluene;