Propanamide,2,2-dimethyl-N-(phenylmethyl)-

Base Information

• Chemical Name: Propanamide,2,2-dimethyl-N-(phenylmethyl)-
• CAS No.: 26209-45-0
• Molecular Formula: C12H17 N O
• Molecular Weight: 191.273
• Hs Code.: 2924299090
• Mol file: 26209-45-0.mol

Synonyms:Propionamide,N-benzyl-2,2-dimethyl- (6CI,7CI,8CI); N-Benzyl-2,2-dimethylpropanamide;N-Benzyl-2,2-dimethylpropionamide; N-Benzylpivalamide; NSC 223052

Chemical Property of Propanamide,2,2-dimethyl-N-(phenylmethyl)-

Chemical Property:

• Vapor Pressure: 3.91E-05mmHg at 25°C
• Boiling Point: 352.2°Cat760mmHg
• Flash Point: 210.4°C
• PSA: 29.10000
• Density: 0.984g/cm³
• LogP: 2.73980

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanamide,2,2-dimethyl-N-(phenylmethyl)-

There total 106 articles about Propanamide,2,2-dimethyl-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzylamine (100-46-9) + Trimethylacetic acid (75-98-9) → N-benzyl-2,2-dimethylpropanamide (26209-45-0)

Guidance literature:

With diphosphorus tetraiodide; In tetrachloromethane; dichloromethane; Heating;

DOI:10.1246/cl.1983.449

Reference yield: 100.0%

pivaloyl chloride (3282-30-2) + benzylamine (100-46-9) → N-benzyl-2,2-dimethylpropanamide (26209-45-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 1h;

DOI:10.1055/s-2002-19803

Reference yield: 99.0%

2,2-dimethylpropanoic anhydride (1538-75-6) + benzylamine (100-46-9) → N-benzyl-2,2-dimethylpropanamide (26209-45-0)

Guidance literature:

2,2-dimethylpropanoic anhydride; With molybdenium(VI) dioxodichloride; In dichloromethane; at 20 ℃; for 0.5h;

benzylamine; In dichloromethane; at 20 ℃; for 0.3h;

DOI:10.1021/jo048363v

upstream raw materials:

pivaloyl chloride

benzylamine

N-(3,3-dimethylbutan-2-ylidene)(phenyl)methanamine

1-ethoxyvinyl pivalate

Downstream raw materials:

N-benzyl-N-nitrosopivalamide

N-acetyl-N-benzylacetamide

N-benzyl-2,2-dimethylpropanethioamide

N-benzyl-2,2-dimethylhex-5-en-3-ylamine

Refernces

• 1、 Ghorpade, Seema A.,Sawant, Dinesh N.,Sekar, Nagaiyan. "Triphenyl borate catalyzed synthesis of amides from carboxylic acids and amines". . p. 6954 - 6958. Retrieved 2018.
• 2、 Boyle, Mhairi,Livingstone, Keith,Henry, Martyn C.,Elwood, Jessica M. L.,Lopez-Fernandez, J. Daniel,Jamieson, Craig. "Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides". . p. 334 - 338. Retrieved 2022/01/20.
• 3、 D'Amaral, Melissa C.,Jamkhou, Nick,Adler, Marc J.. "Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines". supporting information. p. 288 - 295. Retrieved 2021/01/28.