1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methylphenyl)ethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methylphenyl)ethyl ester
• CAS No.: 910575-72-3
• Molecular Formula: C25H28ClN3O6
• Molecular Weight: 501.967

Synonyms:

Chemical Property of 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methylphenyl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methylphenyl)ethyl ester

There total 4 articles about 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methylphenyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-benzyloxy-3-chloro-5-methyl-phenyl)-1-carboxy-ethyl ester (910575-71-2) → 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methyl-phenyl)-ethyl ester (910575-72-3)

Guidance literature:

With hydrogen; 5wt.% Rh on activated alumina; In methanol; dichloromethane; at 40 ℃; for 32h; under 2250.23 Torr;

Reference yield:

C26H30ClN3O6 → 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methyl-phenyl)-ethyl ester (910575-72-3)

Guidance literature:

C₂₆H₃₀ClN₃O₆; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

methanol (67-56-1) + 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-benzyloxy-3-chloro-5-methyl-phenyl)-1-carboxy-ethyl ester (910575-71-2) → 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-carboxy-2-(3-chloro-4-hydroxy-5-methyl-phenyl)-ethyl ester (910575-72-3) + C26H30ClN3O6

Guidance literature:

With hydrogen; Rh/Al₂O₃; at 40 ℃; for 24h;

upstream raw materials:

4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-benzyloxy-3-chloro-5-methyl-phenyl)-1-carboxy-ethyl ester

methanol

4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-benzyloxy-3-chloro-5-methyl-phenyl)-1-methoxycarbonyl-ethyl ester

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