CARBOXYMEFLOQUINE

Base Information

Chemical Name:CARBOXYMEFLOQUINE
CAS No.:35853-50-0
Molecular Formula:C12H5F6NO2
Molecular Weight:309.168
Hs Code.:
Mol file:35853-50-0.mol

Synonyms:Carboxymefloquine;Ro 21-5104;2,8-bis(trifluoromethyl)quinoline-4-carboxylic acid;4-quinolinecarboxylic acid, 2,8-bis(trifluoromethyl)-;

Suppliers and Price of CARBOXYMEFLOQUINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Carboxymefloquine
5mg
$ 460.00

TRC
Carboxymefloquine
50mg
$ 1135.00

TRC
Carboxymefloquine
5mg
$ 145.00

Crysdot
2,8-Bis(trifluoromethyl)quinoline-4-carboxylicacid 98%
5g
$ 1340.00

Crysdot
2,8-Bis(trifluoromethyl)quinoline-4-carboxylicacid 98%
100mg
$ 124.00

Crysdot
2,8-Bis(trifluoromethyl)quinoline-4-carboxylicacid 98%
250mg
$ 178.00

Crysdot
2,8-Bis(trifluoromethyl)quinoline-4-carboxylicacid 98%
1g
$ 446.00

Chemtos
CarboxyMefloquine
50 mg
$ 1045.00

Chemenu
2,8-Bis(trifluoromethyl)quinoline-4-carboxylicacid 98%
5g
$ 1262.00

Chemenu
2,8-Bis(trifluoromethyl)quinoline-4-carboxylicacid 98%
1g
$ 421.00

Total 18 raw suppliers

Chemical Property of CARBOXYMEFLOQUINE

Chemical Property:

Appearance/Colour:Off-white to beige solid
Vapor Pressure:6.48E-05mmHg at 25°C
Melting Point:212-214 °C
Refractive Index:1.513
Boiling Point:330.8 °C at 760 mmHg
PKA:1.47±0.10(Predicted)
Flash Point:153.9 °C
PSA：50.19000
Density:1.574 g/cm³
LogP:3.97060
Storage Temp.:-20°C Freezer
Solubility.:Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Carboxymefloquine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Carboxymefloquine is a metabolite of Mefloquine (M207050).

Technology Process of CARBOXYMEFLOQUINE

There total 3 articles about CARBOXYMEFLOQUINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline

: 124-38-9,18923-20-1
carbon dioxide

: 35853-50-0
2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid

Guidance literature:: With n-butyllithium; In diethyl ether; at -35 ℃; for 0.333333h;
DOI:10.3762/bjoc.12.16

Reference yield:

: 68682-28-0
mefloquine hydrochloride

: 35853-41-9
2,8-bis(trifluoromethyl)quinolin-4-ol

: 57120-56-6
2,8-bis(trifluoromethyl)-4-quinoline carboxaldehyde

: 35853-50-0
2,8-bis-(trifluoromethyl)-quinoline-4-carboxylic acid

: 2-oxo-8-trifluoromethyl-1,2-dihydro-quinoline-4-carbaldehyde

Guidance literature:: With sodium hydroxide; potassium dihydrogenphosphate; oxygen; In methanol; water; for 0.583333h; pH=7.4; Further Variations:; pH-values; Reagents; Solvents; O2 conc., ionic strength, buffer conc., addition of scavengers; Kinetics; Quantum yield; Irradiation;