Technology Process of Phosphoric acid, mono(2-bromoethyl)
mono[3-(hexadecyloxy)-2-(phenylmethoxy)propyl] ester, (R)-
There total 25 articles about Phosphoric acid, mono(2-bromoethyl)
mono[3-(hexadecyloxy)-2-(phenylmethoxy)propyl] ester, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 63 percent / p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating
2: 99 percent / LiAlH4-AlCl3 / CH2Cl2; diethyl ether / 1 h / Heating
3: 98 percent / p-toluenesulfonic acid monohydrate / 1 h / Heating
4: 88 percent / KH (22percent) / benzene / 2 h / Heating
5: 91 percent / HCl (2N) / tetrahydrofuran / 3 h / Ambient temperature
6: Pb(OAc)4 / benzene / 2 h / Ambient temperature
7: NaBH4 / methanol; tetrahydrofuran / Ambient temperature
8: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h
With
lead(IV) acetate; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; potassium chloride; potassium hydride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1248/cpb.33.572
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / LiAlH4-AlCl3 / CH2Cl2; diethyl ether / 1 h / Heating
2: 1.) triethylorthoformate, p-TsOH / 1.) toluene, room temp., 2h; 2.) room temp., 24 h
3: 74 percent / 4,4-dimethylaminopyridine / pyridine / 50 °C
4: 90 percent / acetic acid / ethanol / 48 h / Ambient temperature
5: 1.) NaIO4; 2.) NaBH4 / 1.) 90percent aqueous methanol, 0 deg C, 2 h; 2.) 0 deg C, 2 h
6: 85 percent / KH (22percent) / benzene / Heating
7: 92 percent / p-toluenesulfonic acid monohydrate / methanol / Heating
8: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h
With
dmap; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; aluminium trichloride; potassium chloride; potassium hydride; toluene-4-sulfonic acid; acetic acid; triethylamine; orthoformic acid triethyl ester;
In
pyridine; methanol; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1248/cpb.33.572
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) triethylorthoformate, p-TsOH / 1.) toluene, room temp., 2h; 2.) room temp., 24 h
2: 74 percent / 4,4-dimethylaminopyridine / pyridine / 50 °C
3: 90 percent / acetic acid / ethanol / 48 h / Ambient temperature
4: 1.) NaIO4; 2.) NaBH4 / 1.) 90percent aqueous methanol, 0 deg C, 2 h; 2.) 0 deg C, 2 h
5: 85 percent / KH (22percent) / benzene / Heating
6: 92 percent / p-toluenesulfonic acid monohydrate / methanol / Heating
7: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h
With
dmap; sodium tetrahydroborate; sodium periodate; potassium chloride; potassium hydride; toluene-4-sulfonic acid; acetic acid; triethylamine; orthoformic acid triethyl ester;
In
pyridine; methanol; ethanol; benzene;
DOI:10.1248/cpb.33.572
