1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate

Base Information

Chemical Name:1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate
CAS No.:91444-55-2
Molecular Formula:C19H17NO4
Molecular Weight:323.348
Hs Code.:
DSSTox Substance ID:DTXSID901189608

Synonyms:1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate;91444-55-2;DTXSID901189608;[4-(5-acetyloxy-3-methyl-1H-indol-2-yl)phenyl] acetate

Suppliers and Price of 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:323.11575802
Heavy Atom Count:24
Complexity:472

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(NC2=C1C=C(C=C2)OC(=O)C)C3=CC=C(C=C3)OC(=O)C

Technology Process of 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate

There total 7 articles about 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 25743-57-1
1-(4-acetoxy-phenyl)-2-bromo-propan-1-one

: 2623-33-8
4-acetoxyacetanilide

: 91444-55-2
4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 110 ℃; for 10h; Solvent; Temperature; Reagent/catalyst;

Reference yield: 80.0%

: 64-19-7,77671-22-8
acetic acid

: 91444-54-1
2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

: 75-36-5
acetyl chloride

: 91444-55-2
4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate

Guidance literature:: at 20 ℃; for 10h;

Reference yield:

: 21086-33-9
2-bromo-1-(4-methoxyphenyl)-1-propanone

: 91444-55-2
4-(5-acetoxy-3-methyl-1H-indol-2-yl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethylaniline / 170 °C

2: BBr₃ / CH₂Cl₂ / -60 - 20 °C

3: pyridine / 2 h / Heating

With pyridine; boron tribromide; N,N-dimethyl-aniline; In dichloromethane;
DOI:10.1021/jm00377a011