Chemical Property of Bazedoxifene
Chemical Property:
- Vapor Pressure:6.33E-20mmHg at 25°C
- Melting Point:98-102°
- Refractive Index:1.622
- Boiling Point:694.4 °C at 760 mmHg
- PKA:10.12±0.15(Predicted)
- Flash Point:373.8 °C
- PSA：57.86000
- Density:1.19 g/cm3
- LogP:6.26890
- Storage Temp.:Sealed in dry,Store in freezer, under -20°C
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:6.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:7
- Exact Mass:470.25694295
- Heavy Atom Count:35
- Complexity:623
- Purity/Quality:
-
99%, *data from raw suppliers
Bazedoxifene *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O
- Recent ClinicalTrials:A Study of Palbociclib in Combination With Bazedoxifene in Hormone Receptor Positive Breast Cancer
- Recent EU Clinical Trials:A 2-Part, Open-label, Non-randomized (Part A) and Randomized, Double-blinded, Placebo-controlled (Part B) multicentric, international study with adaptive design to evaluate safety and tolerability of bazedoxifene, concentrated solution for nebulization (BAZE-X1) in addition to Standard of Care in hospitalized COVID-19 patients suffering from moderate to severe Pneumonia.
- Recent NIPH Clinical Trials:The effects of bazedoxifene and estradiol on the bone mineral density and bone turnover markers in postmenopausal women
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Uses
Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.
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Clinical Use
Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of
postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated
estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for
the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a
beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.
