(3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Base Information

Chemical Name:(3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CAS No.:36396-99-3
Molecular Formula:C16H23 N5 O4
Molecular Weight:349.39
Hs Code.:29349990
DSSTox Substance ID:DTXSID70957734
Mol file:36396-99-3.mol

Synonyms:(3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol;Adenosine, N-cyclohexyl-;DTXSID70957734

Suppliers and Price of (3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N6-Cyclohexyladenosine
500mg
$ 745.00

Tocris
N6-Cyclohexyladenosine ≥98%(HPLC)
50
$ 85.00

Sigma-Aldrich
N6-Cyclohexyladenosine
250mg
$ 361.00

Sigma-Aldrich
N6-Cyclohexyladenosine
50mg
$ 97.60

DC Chemicals
N6-Cyclohexyladenosine >98%
1 g
$ 600.00

DC Chemicals
N6-Cyclohexyladenosine >98%
100 mg
$ 150.00

Crysdot
N6-Cyclohexyladenosine 98+%
250mg
$ 574.00

Crysdot
N6-Cyclohexyladenosine 98+%
100mg
$ 327.00

ChemScene
N6-Cyclohexyladenosine 99.98%
10mg
$ 60.00

ChemScene
N6-Cyclohexyladenosine 99.98%
50mg
$ 216.00

Total 19 raw suppliers

Chemical Property of (3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:182 - 184°C
Boiling Point:675.2°Cat760mmHg
Flash Point:362.1°C
PSA：125.55000
Density:1.71g/cm³
LogP:0.25540
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
XLogP3:1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:349.17500423
Heavy Atom Count:25
Complexity:452

Purity/Quality:

97% ^*data from raw suppliers

N6-Cyclohexyladenosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CCC(CC1)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O
Isomeric SMILES:C1CCC(CC1)NC2=C3C(=NC=N2)N(C=N3)C4[C@@H]([C@@H](C(O4)CO)O)O
Description N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively). N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).
Uses N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.

Technology Process of (3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

There total 8 articles about (3R,4S)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%