N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide

Base Information

• Chemical Name: N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide
• CAS No.: 3968-03-4
• Molecular Formula: C13H11 Cl N2 O4 S
• Molecular Weight: 326.76
• Mol file: 3968-03-4.mol

Synonyms:p-Toluenesulfonanilide,4'-chloro-2'-nitro- (7CI,8CI); 4'-Chloro-2'-nitro-p-toluenesulfonanilide

Chemical Property of N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide

Chemical Property:

• Vapor Pressure: 4.69E-13mmHg at 25°C
• Boiling Point: 571.1°Cat760mmHg
• Flash Point: 299.2°C
• Density: 1.558g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide

There total 3 articles about N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-N-(4-chlorophenyl)benzenesulfonamide (2903-34-6) → N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (3968-03-4)

Guidance literature:

With nitric acid; In water; acetic acid; at 50 ℃;

Reference yield: 96.0%

2-fluoro-5-chloronitrobenzene (345-18-6) + toluene-4-sulfonamide (70-55-3) → N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (3968-03-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 0.2h; Microwave irradiation;

DOI:10.1016/j.tetlet.2019.01.041

Reference yield:

4-chloro-aniline (106-47-8) + p-toluenesulfonyl chloride (98-59-9) → N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide (3968-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Reflux

2: tert.-butylnitrite / acetonitrile / 24 h / 45 °C

With pyridine; tert.-butylnitrite; In acetonitrile;

DOI:10.1039/c2cc37481a

upstream raw materials:

4-methyl-N-(4-chlorophenyl)benzenesulfonamide

4-chloro-aniline

p-toluenesulfonyl chloride

2-fluoro-5-chloronitrobenzene

Downstream raw materials:

N-(2-bromoethyl)-4'-chloro-2'-nitro-p-toluenesulfonanilide

N-(4-chloro-2-nitro-phenyl)-N-ethyl-4-methyl-benzenesulfonamide

Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide

N-[(Z)-3-Chloro-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-N'-phenyl-hydrazine