(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

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Chemical Name:(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene
CAS No.:86670-99-7
Molecular Formula:C₂₀H₂₂ClN₃O₃S₂
Molecular Weight:451.998
Hs Code.:

Synonyms:(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

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Chemical Property of (Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

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Technology Process of (Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

There total 5 articles about (Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 86662-09-1
Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-chloro-phenyl}-amide

: 86670-99-7
(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

Guidance literature:: With triethylamine; In ethanol; Heating;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 3968-03-4
N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide

: 86670-99-7
(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaOMe / 1) methanol, reflux, 2) DMF, 120 deg C

2: H₂ / 8percent Pd-C / dioxane / Ambient temperature

3: H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

4: 83 percent / diethyl ether / 0.17 h / Heating

5: 66 percent / Et₃N / ethanol / Heating

With hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 86661-97-4
N-(2-bromoethyl)-4'-chloro-2'-nitro-p-toluenesulfonanilide

: 86670-99-7
(Z)-3-Chloro-6-morpholin-4-yl-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocyclooctene

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 8percent Pd-C / dioxane / Ambient temperature

2: H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

3: 83 percent / diethyl ether / 0.17 h / Heating

4: 66 percent / Et₃N / ethanol / Heating

With hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water;
DOI:10.1016/S0040-4020(01)91886-1