5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-7-oxo-6-(phenylmethyl)-, ethyl ester

Base Information

• Chemical Name: 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-7-oxo-6-(phenylmethyl)-, ethyl ester
• CAS No.: 915296-87-6
• Molecular Formula: C24H20Cl2N2O3
• Molecular Weight: 455.34
• Mol file: 915296-87-6.mol

Synonyms:

Chemical Property of 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-7-oxo-6-(phenylmethyl)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-7-oxo-6-(phenylmethyl)-, ethyl ester

There total 4 articles about 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-7-oxo-6-(phenylmethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylate (915296-86-5) → Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915296-87-6)

Guidance literature:

With nitric acid; In water; at 20 ℃; for 0.5h; Heating / reflux;

Reference yield:

ethyl-3-benzylamino propionate (23583-21-3) → Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915296-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 1 h / Reflux

1.2: 4 h / Reflux

2.1: acetic acid / 1.5 h / Reflux

3.1: nitric acid / 0.5 h / Reflux

With nitric acid; sodium ethanolate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2011.09.074

Reference yield:

benzylamine (100-46-9) → Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915296-87-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethanol / 15 h / 20 °C

2.1: sodium ethanolate / ethanol / 1 h / Reflux

2.2: 4 h / Reflux

3.1: acetic acid / 1.5 h / Reflux

4.1: nitric acid / 0.5 h / Reflux

With nitric acid; sodium ethanolate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2011.09.074

upstream raw materials:

Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylate

1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione

ethyl-3-benzylamino propionate

benzylamine

Downstream raw materials:

6-Benzyl-4-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-methyl-5,6-dihydropyrrolo[3,4-b]pyridin-7-one

Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-6H-pyrrolo[3,4-b]pyridine-3-carboxylate

(6-Benzyl-4-(2,4-dichlorophenyl)-2-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methanol

C₂₂H₁₉Cl₃N₂