1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione

Base Information

• Chemical Name: 1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione
• CAS No.: 1135991-71-7
• Molecular Formula: C₁₈H₁₃Cl₂NO₂
• Molecular Weight: 346.213
• Mol file: 1135991-71-7.mol

Synonyms:1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione

Chemical Property of 1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione

There total 1 articles about 1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-3-benzylamino propionate (23583-21-3) + 2,4-dichlorobenzaldeyhde (874-42-0) + oxalic acid diethyl ester (95-92-1) → 1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione (1135991-71-7)

Guidance literature:

ethyl-3-benzylamino propionate; oxalic acid diethyl ester; With sodium ethanolate; In ethanol; for 1h; Reflux;

2,4-dichlorobenzaldeyhde; With hydrogenchloride; In ethanol; water; for 4h; Reflux;

DOI:10.1016/j.bmcl.2011.09.074

Reference yield: 94.0%

1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione (1135991-71-7) + 2-(p-chlorobenzoylmethylene)imidazolidine (107165-82-2) → 2-benzyl-5-(4-chlorobenzoyl)-4-(2,4-dichlorophenyl)-9a-hydroxy-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one (1603163-32-1)

Guidance literature:

In ethanol; at 40 ℃; for 6h; Green chemistry;

DOI:10.1039/c3ra45485a

Reference yield: 94.0%

1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione (1135991-71-7) + 2-benzoylmethyleneimidazolidine (64944-80-5) → 5-benzoyl-2-benzyl-4-(2,4-dichlorophenyl)-9a-hydroxy-2,3,3a,4,6,7,8,9a-octahydro-1H-imidazo[1,2-a]pyrrolo[3,4-e]pyridin-1-one (1603163-36-5)

Guidance literature:

In ethanol; at 40 ℃; for 6h; Green chemistry;

DOI:10.1039/c3ra45485a

upstream raw materials:

ethyl-3-benzylamino propionate

2,4-dichlorobenzaldeyhde

oxalic acid diethyl ester

Downstream raw materials:

Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate

6-Benzyl-4-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-methyl-5,6-dihydropyrrolo[3,4-b]pyridin-7-one

C₂₂H₁₇Cl₃N₂O

Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-6H-pyrrolo[3,4-b]pyridine-3-carboxylate