Ethyl 2-chloro-6-nitroquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 2-chloro-6-nitroquinoline-3-carboxylate
CAS No.:91538-58-8
Molecular Formula:C12H9ClN2O4
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID40534738
Wikidata:Q82408699

Synonyms:Ethyl 2-chloro-6-nitroquinoline-3-carboxylate;91538-58-8;DTXSID40534738

Suppliers and Price of Ethyl 2-chloro-6-nitroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Ethyl 2-chloro-6-nitroquinoline-3-carboxylate

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:280.0250845
Heavy Atom Count:19
Complexity:360

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C2C=CC(=CC2=C1)[N+](=O)[O-])Cl

Technology Process of Ethyl 2-chloro-6-nitroquinoline-3-carboxylate

There total 7 articles about Ethyl 2-chloro-6-nitroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 85870-48-0
1,2-dihydro-6-nitro-2-oxo-3-quinolinecarboxylic acid ethyl ester

: 91538-58-8
2-chloro-6-nitro-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; at 100 ℃; for 7h; Inert atmosphere;

Reference yield:

: 17422-56-9
diethyl 2-(2-nitrobenzylidene)malonate

: 91538-58-8
2-chloro-6-nitro-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 48.5 g / H₂ / Raney Ni / ethanol

2: 10.7 g / 96percent H₂SO₄, 70percent HNO₃ / 1 h / 0 °C

3: 1.14 g / POCl₃ / 2.75 h / Heating

With sulfuric acid; hydrogen; nitric acid; trichlorophosphate; nickel; In ethanol;

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 91538-58-8
2-chloro-6-nitro-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / KHCO₃ / acetic anhydride / 2 h / Heating

2: 48.5 g / H₂ / Raney Ni / ethanol

3: 10.7 g / 96percent H₂SO₄, 70percent HNO₃ / 1 h / 0 °C

4: 1.14 g / POCl₃ / 2.75 h / Heating

With sulfuric acid; hydrogen; nitric acid; potassium hydrogencarbonate; trichlorophosphate; nickel; In ethanol; acetic anhydride;