2-Amino-5-nitrobenzaldehyde

Base Information

• Chemical Name: 2-Amino-5-nitrobenzaldehyde
• CAS No.: 56008-61-8
• Molecular Formula: C7H6 N2 O3
• Molecular Weight: 166.136
• Hs Code.: 2922390090
• NSC Number: 129607
• DSSTox Substance ID: DTXSID10299362
• Wikidata: Q82041721
• Mol file: 56008-61-8.mol

Synonyms:2-amino-5-nitrobenzaldehyde;56008-61-8;2-AMINO-5-NITRO-BENZALDEHYDE;Benzaldehyde, 2-amino-5-nitro-;NSC129607;SCHEMBL2923685;DTXSID10299362;MFCD09834917;AKOS006327499;AB52848;NSC 129607;NSC-129607;BS-28877;EN300-175026;F15866;Z1198233260

Chemical Property of 2-Amino-5-nitrobenzaldehyde

Chemical Property:

• Vapor Pressure: 5.26E-06mmHg at 25°C
• Boiling Point: 380.9°Cat760mmHg
• Flash Point: 184.2°C
• PSA: 88.91000
• Density: 1.441g/cm³
• LogP: 2.09390
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 166.03784206
• Heavy Atom Count: 12
• Complexity: 190

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-nitrobenzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C=O)N

Technology Process of 2-Amino-5-nitrobenzaldehyde

There total 8 articles about 2-Amino-5-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(2-formyl-4-nitrophenyl)acetamide (91538-60-2) → 2-amino-5-nitrobenzaldehyde (56008-61-8)

Guidance literature:

With sulfuric acid; for 1h; Heating;

DOI:10.1016/S0040-4020(99)00673-0

Reference yield: 83.0%

(2-amino-5-nitrophenyl)methanol (77242-30-9) → 2-amino-5-nitrobenzaldehyde (56008-61-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 23h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.004

Reference yield:

acetic acid-[2-((E)-p-tolylimino-methyl)-anilide] (142598-80-9) → 2-amino-5-nitrobenzaldehyde (56008-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; water / ethanol / 4 h / 20 °C

2: sulfuric acid; nitric acid; acetic acid / 0 - 20 °C

3: hydrogenchloride / water / 8 h / Reflux

With hydrogenchloride; sulfuric acid; water; nitric acid; acetic acid; In ethanol; water;

DOI:10.1016/j.tet.2010.07.048

upstream raw materials:

N-(2-formyl-4-nitrophenyl)acetamide

5-nitro-2-[N-(p-toluenesulfonyl)amino]benzaldehyde

hydrogenchloride

(2-amino-5-nitrophenyl)methanol

Downstream raw materials:

10-nitro-(20RS)-camptothecin

10-nitro-(20S)-camptothecin

1,2-dihydro-6-nitro-2-oxo-3-quinolinecarboxylic acid ethyl ester

2-iodo-5-nitrobenzaldehyde