1-Amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid

Base Information

Chemical Name:1-Amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid
CAS No.:140480-88-2
Molecular Formula:C₆H₁₀NO₅P
Molecular Weight:207.123
Hs Code.:
Nikkaji Number:J668.337A
ChEMBL ID:CHEMBL22136
Mol file:140480-88-2.mol

Synonyms:1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid;cyclobutylene AP5

Suppliers and Price of 1-Amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-Amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid

Chemical Property:

Vapor Pressure:1.22E-12mmHg at 25°C
Boiling Point:529.9°Cat760mmHg
Flash Point:274.2°C
PSA：130.66000
Density:1.898g/cm³
LogP:0.32420
XLogP3:-5.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:207.02965942
Heavy Atom Count:13
Complexity:309

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=CP(=O)(O)O)CC1(C(=O)O)N

Technology Process of 1-Amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid

There total 11 articles about 1-Amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 129287-98-5
ethyl 1-<<(tert-butyloxy)carbonyl>amino>-3-<(diethoxyphosphinyl)methylene>cyclobutane-1-carboxylate

: 140480-88-2
(+/-)-1-amino-3-(phosphonomethylene)cyclobutanecarboxylic acid

Guidance literature:: With hydrogenchloride; for 40h;
DOI:10.1021/jm00172a036

Reference yield:

: 54166-15-3
diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

: 140480-88-2
(+/-)-1-amino-3-(phosphonomethylene)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / aq. KOH / ethanol / 8 h / Heating

2: 1.) diphenyl phosphorazidate, triethylamine / 1.) a) toluene, 80 deg C, 1 h, b) 110 deg C, 1 h, 2.) 110 deg C, 48 h

3: 4.05 g / H₂ / 10percent Pd/C / ethanol / 96 h / 760 Torr

4: 80 percent / sodium metaperiodate, RuO₄ / H₂O; CCl₄

5: 26 percent / NaH / dioxane / Ambient temperature

6: 74 percent / 6M aq.HCl / 40 h

With hydrogenchloride; potassium hydroxide; sodium periodate; ruthenium tetroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; tetrachloromethane; ethanol; water;
DOI:10.1021/jm00172a036

Reference yield:

: 180205-43-0
3-(benzyloxy)-1-carbethoxycyclobutane-1-carboxylic acid

: 140480-88-2
(+/-)-1-amino-3-(phosphonomethylene)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) diphenyl phosphorazidate, triethylamine / 1.) a) toluene, 80 deg C, 1 h, b) 110 deg C, 1 h, 2.) 110 deg C, 48 h

2: 4.05 g / H₂ / 10percent Pd/C / ethanol / 96 h / 760 Torr

3: 80 percent / sodium metaperiodate, RuO₄ / H₂O; CCl₄

4: 26 percent / NaH / dioxane / Ambient temperature

5: 74 percent / 6M aq.HCl / 40 h

With hydrogenchloride; sodium periodate; ruthenium tetroxide; diphenyl phosphoryl azide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; tetrachloromethane; ethanol; water;
DOI:10.1021/jm00172a036