1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE

Base Information

• Chemical Name: 1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE
• CAS No.: 273-05-2
• Molecular Formula: C5H4 N4
• Molecular Weight: 120.114
• Hs Code.: 2933990090
• Mol file: 273-05-2.mol

Synonyms:1H-1,2,3-Triazolo[4,5-c]pyridine(9CI); 1H-v-Triazolo[4,5-c]pyridine (8CI); NSC 611394;[1,2,3]Triazolo[4,5-c]pyridine

Chemical Property of 1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE

Chemical Property:

• Vapor Pressure: 0.000175mmHg at 25°C
• Melting Point: 186-187 °C
• Boiling Point: 329.6°Cat760mmHg
• PKA: 7.00±0.70(Predicted)
• Flash Point: 169.3°C
• PSA: 54.46000
• Density: 1.472g/cm³
• LogP: 0.35290
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3H-1,2,3-Triazolo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3H-1,2,3-Triazolo[4,5-c]pyridine is an N-acylating and N-alkoxycarbonylation reagent that can be used as a P2X7 modulator for therapy. It can also be used as an inhibitor of hormone-sensitive lipase (HSL) and endothelial lipase (EL).

Technology Process of 1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE

There total 9 articles about 1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

benzylamine (100-46-9) + 3-amino-4-pyridylcarbamic acid methyl ester (623562-26-5) → 1H-[1.2.3]triazolo-(4,5-c)pyridine (273-05-2) + methyl N-benzylcarbamate (5817-70-9)

Guidance literature:

3-amino-4-pyridylcarbamic acid methyl ester; With nitrosonium tetrafluoroborate; In acetonitrile; at 0 ℃; for 0.333333h;

benzylamine; In acetonitrile; at 20 ℃;

DOI:10.1002/jhet.5570430223

Reference yield: 76.0%

N-(3-aminopyridin-4-yl)acetamide (145255-15-8) + isopropylamine (75-31-0) → 1H-[1.2.3]triazolo-(4,5-c)pyridine (273-05-2) + N-isopropylacetamide (1118-69-0)

Guidance literature:

N-(3-aminopyridin-4-yl)acetamide; With nitrosonium tetrafluoroborate; In acetonitrile; at 0 ℃; for 0.333333h;

isopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1002/jhet.5570430223

Reference yield: 74.0%

isopropylamine (75-31-0) + (3-Amino-pyridin-4-yl)-carbamic acid tert-butyl ester (183311-28-6) → 1H-[1.2.3]triazolo-(4,5-c)pyridine (273-05-2) + tert-butyl N-isopropylcarbamate (51170-55-9)

Guidance literature:

(3-Amino-pyridin-4-yl)-carbamic acid tert-butyl ester; With nitrosonium tetrafluoroborate; In acetonitrile; at 0 ℃; for 0.333333h;

isopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1002/jhet.5570430223

upstream raw materials:

3-amino-4-pyridinylcarbamic acid ethyl ester

isopropylamine

N-(3-aminopyridin-4-yl)acetamide

(3-Amino-pyridin-4-yl)-carbamic acid tert-butyl ester

Downstream raw materials:

1-(2-nitrophenyl) triazolo <4,5-c> pyridine

2,4,8,10-tetranitropyrido[3'',4'':4',5'][1,2,3]triazolo[2',1':2,3][1,2,3]triazolo[4,5-b]pyridin-6-ium inner salt

1-phenyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridine

1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine