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tert-Butyl isopropylcarbamate, also known as tert-Butyl N-(Propan-2-yl)carbamate, is an organic compound that serves as an intermediate in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
tert-Butyl isopropylcarbamate is used as an intermediate in the synthesis of N-Ethyl-N-nitroso-2-propanamine (E932795) for the production of Amino Acids, Peptides, and Proteins. This intermediate plays a crucial role in the development of pharmaceutical compounds and contributes to the advancement of drug discovery and synthesis processes.

51170-55-9

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51170-55-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 51170-55-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,1,7 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 51170-55:
(7*5)+(6*1)+(5*1)+(4*7)+(3*0)+(2*5)+(1*5)=89
89 % 10 = 9
So 51170-55-9 is a valid CAS Registry Number.

51170-55-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-propan-2-ylcarbamate

1.2 Other means of identification

Product number -
Other names tert-butyl N-isopropylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51170-55-9 SDS

51170-55-9Relevant articles and documents

ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS

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Paragraph 00426; 00427, (2021/01/29)

The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.

Tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

Du, Fangyu,Zhou, Qifan,Fu, Yang,Zhao, Hanqi,Chen, Yuanguang,Chen, Guoliang

supporting information, p. 6549 - 6554 (2019/05/04)

The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity and chemoselectivity of this novel Boc reagent. The reaction was carried out chemoselectively in high yield under mild, environment-friendly conditions and was completed quickly within 1 hour. Simultaneously, the Boc carrier was easily recyclable, and has great application prospects for industrial production.

Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

Li, Peihe,Ma, Nuannuan,Wang, Zheng,Dai, Qipu,Hu, Changwen

, p. 8233 - 8240 (2018/05/31)

A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.

Efficient and expeditious chemoselective BOC protection of amines in catalyst and solvent-free media

Viswanadham, Balaga,Mahomed, Abdul S.,Friedrich, Holger B.,Singh, Sooboo

, p. 1355 - 1363 (2017/02/15)

A green and eco-friendly route for the almost quantitative BOC protection of a large variety of aliphatic and aromatic amines, amino acids, and amino alcohols is reported in catalyst and solvent-free media under mild reaction conditions. The products were confirmed by 1H, 13C NMR, IR spectroscopy, and in some cases, elemental analysis. This protocol does not require any water quenches, solvent separations, and purification steps, such as recrystallization and column chromatography.

Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up

Remarchuk, Travis,St-Jean, Frederic,Carrera, Diane,Savage, Scott,Yajima, Herbert,Wong, Brian,Babu, Srinivasan,Deese, Alan,Stults, Jeffrey,Dong, Michael W.,Askin, David,Lane, Jonathan W.,Spencer, Keith L.

supporting information, p. 1652 - 1666 (2015/02/19)

Herein, the first-generation process to manufacture Akt inhibitor Ipatasertib through a late-stage convergent coupling of two challenging chiral components on multikilogram scale is described. The first of the two key components is a trans-substituted cyc

Asymmetric aminolytic kinetic resolution of racemic epoxides using recyclable chiral polymeric Co(III)-salen complexes: A protocol for total utilization of racemic epoxide in the synthesis of (R)-naftopidil and (S)-propranolol

Kumar, Manish,Kureshy, Rukhsana I.,Shah, Arpan K.,Das, Anjan,Khan, Noor-Ul H.,Abdi, Sayed H. R.,Bajaj, Hari C.

, p. 9076 - 9084 (2013/10/08)

Chiral polymeric Co(III) salen complexes with chiral ((R)/(S)-BINOL, diethyl tartrate) and achiral (piperazine and trigol) linkers with varying stereogenic centers were synthesized for the first time and used as catalysts for aminolytic kinetic resolution (AKR) of a variety of terminal epoxides and glycidyl ethers to get enantio-pure epoxides (ee, 99%) and N-protected β-amino alcohols (ee, 99%) with quantitative yield in 16 h at RT under optimized reaction conditions. This protocol was also used for the synthesis of two enantiomerically pure drug molecules (R)-Naftopidil (α1- blocker) and (S)-Propranolol (β-blocker) as a key step via AKR of single racemic naphthylglycidyl ether with Boc-protected isoproylamine with 100% epoxide utilization at 1 g level. The catalyst 1 was successfully recycled for a number of times.

Diazeniumdiolated carbamates: A novel class of nitric oxide donors

Nandurdikar, Rahul S.,MacIag, Anna E.,Cao, Zhao,Keefer, Larry K.,Saavedra, Joseph E.

, p. 2025 - 2029 (2012/05/07)

We report an indirect method for synthesis of previously inaccessible diazeniumdiolated carbamates. Synthesis involves use of previously reported triisopropylsilyloxymethylated isopropylamine diazeniumdiolate (TOM-ylated IPA/NO). These novel diazeniumdiolated carbamate prodrugs upon activation release nitric oxide (NO) similar to their secondary amine counterparts. They are also efficient sources of intracellular NO. These prodrugs may have potential applications as therapeutic NO-donors.

PEG-mediated facile protocol for N-Boc protection of amines

Siddaiah,Basha,Padma Rao,Viplava Prasad,Suryachendra Rao

experimental part, p. 1127 - 1129 (2011/02/28)

We have reported an efficient and eco-friendly protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of PEG-400 at room temperature. The reaction gave excellent

Deuterium exchange as an indicator of hydrogen bond donors and acceptors

Steffel, Lauren R.,Cashman, Timothy J.,Reutershan, Michael H.,Linton, Brian R.

, p. 12956 - 12957 (2008/09/17)

Hydrogen-deuterium exchange has been used to determine the hydrogen bonding preferences of a select group of small peptides in organic solvents. This kinetic analysis permitted comparison of hydrogen bond strengths in relation to controls and also indicated the identity of both hydrogen bond donors and hydrogen bond acceptors. Copyright

β-Sheet hydrogen bonding patterns in cystine peptides

Cashman, Timothy J.,Linton, Brian R.

, p. 5457 - 5460 (2008/09/18)

Cystine peptides have been shown to adopt conformations in organic solvents that mimic small β-sheets. Relative hydrogen bond strengths, β-strand aggregation, and the identity of individual hydrogen bond donors and acceptors have been identified through h

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