8-Bromo-7-chloro-2-methoxy-[1,5]naphthyridine

Base Information

• Chemical Name: 8-Bromo-7-chloro-2-methoxy-[1,5]naphthyridine
• CAS No.: 915976-85-1
• Molecular Formula: C₉H₆BrClN₂O
• Molecular Weight: 273.516
• Mol file: 915976-85-1.mol

Synonyms:8-bromo-7-chloro-2-methoxy-[1,5]naphthyridine;8-bromo-7-chloro-2-(methyloxy)-1,5-naphthyridine;8-bromo-7-chloro-2-(methyloxy)-[1,5]naphthyridine;

Chemical Property of 8-Bromo-7-chloro-2-methoxy-[1,5]naphthyridine

Chemical Property:

• Boiling Point: 347.2±37.0 °C(Predicted)
• PKA: 0.23±0.10(Predicted)
• PSA: 35.01000
• Density: 1.686±0.06 g/cm3(Predicted)
• LogP: 3.05430

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-7-chloro-2-methoxy-[1,5]naphthyridine ＞97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Bromo-7-chloro-2-methoxy-[1,5]naphthyridine

There total 6 articles about 8-Bromo-7-chloro-2-methoxy-[1,5]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-chloro-6-(methyloxy)-[1,5]naphthyridin-4(1H)-one (1073495-87-0,724787-12-6) → 8-bromo-7-chloro-2-methoxy-1,5-naphthyridine (915976-85-1)

Guidance literature:

3-chloro-6-(methyloxy)-[1,5]naphthyridin-4(1H)-one; With phosphorus tribromide; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 1.5h;

With potassium carbonate; In water; N,N-dimethyl-formamide; pH=7;

Reference yield: 84.0%

→ 8-bromo-7-chloro-2-methoxy-1,5-naphthyridine (915976-85-1)

Guidance literature:

With phosphorus tribromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

3-chloro-6-methoxy-1,5-naphthyridin-4-ol (1073495-87-0,724787-12-6) → 8-bromo-7-chloro-2-methoxy-1,5-naphthyridine (915976-85-1)

Guidance literature:

With phosphorus tribromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

upstream raw materials:

3-chloro-6-(methyloxy)-[1,5]naphthyridin-4(1H)-one

3-chloro-6-methoxy-1,5-naphthyridin-4-ol

6-methoxy-pyridin-3-ylamine

5-[[(6-methoxypyridin-3-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

methyl [3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]acetate

[(4R/S)-(3-chloro-4-hydroxy-7-oxo-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-4-yl)]methyl 4-methylbenzenesulfonate

trans-4-(8-methoxy-1,2-dihydro-3-oxa-5,9-diaza-cyclopenta[a]naphthalen-2-ylmethyl)-cyclohexylamine

[trans-4-(8-methoxy-1,2-dihydro-3-oxa-5,9-diaza-cyclopenta[a]naphthalen-2-ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester