3-Chloro-6-methoxy-[1,5]naphthyridin-4-ol

Base Information

• Chemical Name: 3-Chloro-6-methoxy-[1,5]naphthyridin-4-ol
• CAS No.: 1073495-87-0
• Molecular Weight: 210.62
• Mol file: 1073495-87-0.mol

Synonyms:724787-12-6;3-Chloro-6-methoxy-[1,5]naphthyridin-4-ol;3-Chloro-6-methoxy-1,5-naphthyridin-4-ol;1073495-87-0;3-Chloro-6-methoxy-1,5-naphthyridin-4(1H)-one;3-chloro-6-methoxy-1H-1,5-naphthyridin-4-one;3-Chloro-6-methoxy-1H-[1,5]naphthyridin-4-one;starbld0000173;SCHEMBL2768464;BBRMUSGOTQCSET-UHFFFAOYSA-N;CS-0131399;3-chloro-6-(methoxy)-1,5-naphthyridin-4-ol;3-Chloro-6-methoxy-[1,5]-naphthyridin-4-ol;E81545;3-chloro-4-hydroxy-6-methoxy-1,5-naphthyridine;3-chloro-6-(methyloxy)-1,5-naphthyridin-4-ol;3-chloro-6-(methyloxy)-1,5-naphthyridin-4(1H)-one

Chemical Property of 3-Chloro-6-methoxy-[1,5]naphthyridin-4-ol

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 210.0196052
• Heavy Atom Count: 14
• Complexity: 280

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-6-methoxy-1H-[1,5]naphthyridin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NC2=C(C=C1)NC=C(C2=O)Cl

Technology Process of 3-Chloro-6-methoxy-[1,5]naphthyridin-4-ol

There total 3 articles about 3-Chloro-6-methoxy-[1,5]naphthyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-methoxy-1,5-naphthyridin-4-ol (23443-25-6) → 3-chloro-6-methoxy-1,5-naphthyridin-4-ol (1073495-87-0,724787-12-6)

Guidance literature:

With N-chloro-succinimide; In acetic acid; at 35 ℃; for 24h;

Reference yield:

6-methoxy-pyridin-3-ylamine (6628-77-9) → 3-chloro-6-methoxy-1,5-naphthyridin-4-ol (1073495-87-0,724787-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: cycl-isopropylidene malonate / ethanol / 1 h / Reflux

2: diphenyl ether-biphenyl eutectic / 0.08 h / 240 °C

3: acetic acid; N-chloro-succinimide / 4 h / 35 - 40 °C

With N-chloro-succinimide; cycl-isopropylidene malonate; diphenyl ether-biphenyl eutectic; acetic acid; In ethanol;

Reference yield:

5-[[(6-methoxypyridin-3-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (25063-69-8) → 3-chloro-6-methoxy-1,5-naphthyridin-4-ol (1073495-87-0,724787-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl ether-biphenyl eutectic / 0.08 h / 240 °C

2: acetic acid; N-chloro-succinimide / 4 h / 35 - 40 °C

With N-chloro-succinimide; diphenyl ether-biphenyl eutectic; acetic acid;

upstream raw materials:

6-methoxy-1,5-naphthyridin-4-ol

6-methoxy-pyridin-3-ylamine

5-[[(6-methoxypyridin-3-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

[(4R/S)-(3-chloro-4-hydroxy-7-oxo-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-4-yl)]methyl 4-methylbenzenesulfonate

methyl [3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]acetate

8-bromo-7-chloro-2-methoxy-1,5-naphthyridine