Technology Process of Hexanal,
4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-6-(phenylmethoxy)-,
(3S,4R,5S)-
There total 7 articles about Hexanal,
4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-6-(phenylmethoxy)-,
(3S,4R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(methoxymethyl)triphenylphosphonium chloride; (2R,3S,4S)-5-Benzyloxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-pentanal;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -40 - 0 ℃;
for 2h;
With
pyridinium p-toluenesulfonate;
In
1,4-dioxane; water;
at 50 ℃;
for 12h;
DOI:10.1016/j.tetlet.2006.09.004
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 80 percent / DIBAL-H / CH2Cl2 / 3 h / 0 °C
2.1: 91 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 1 h / -78 - 0 °C
3.1: NaHMDS / tetrahydrofuran / 2 h / -40 - 0 °C
3.2: 85 percent / PPTS / dioxane; H2O / 12 h / 50 °C
With
oxalyl dichloride; sodium hexamethyldisilazane; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
2.1: Swern oxidation / 3.1: Wittig reaction;
DOI:10.1016/j.tetlet.2006.09.004
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 1.5 h / -78 - 20 °C
2.1: 97 percent / (-)-sparteine / CH2Cl2 / 1.5 h / 0 °C
3.1: 90 percent / NaBH4 / tetrahydrofuran; H2O / 12 h / 0 - 20 °C
4.1: 70 percent / CSA / CH2Cl2 / 4 h / 20 °C
5.1: 80 percent / DIBAL-H / CH2Cl2 / 3 h / 0 °C
6.1: 91 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 1 h / -78 - 0 °C
7.1: NaHMDS / tetrahydrofuran / 2 h / -40 - 0 °C
7.2: 85 percent / PPTS / dioxane; H2O / 12 h / 50 °C
With
sodium tetrahydroborate; oxalyl dichloride; camphor-10-sulfonic acid; sodium hexamethyldisilazane; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; (-)-sparteine;
In
tetrahydrofuran; dichloromethane; water;
1.1: Swern oxidation / 6.1: Swern oxidation / 7.1: Wittig reaction;
DOI:10.1016/j.tetlet.2006.09.004
