Glafenine

Base Information

• Chemical Name: Glafenine
• CAS No.: 3820-67-5
• Molecular Formula: C19H17ClN2O4
• Molecular Weight: 372.808
• Hs Code.: 2933499090
• European Community (EC) Number: 223-315-7
• NSC Number: 757808
• UNII: 46HL4I09AH
• DSSTox Substance ID: DTXSID1048546
• Nikkaji Number: J3.409F
• Wikipedia: Glafenine
• Wikidata: Q5566483
• NCI Thesaurus Code: C72119
• Metabolomics Workbench ID: 52057
• ChEMBL ID: CHEMBL146095
• Mol file: 3820-67-5.mol

Synonyms:Exidol;Glafenin;Glafenine;Glaphenine;Glycerylaminophenaquine

Chemical Property of Glafenine

Chemical Property:

• Vapor Pressure: 3.92E-16mmHg at 25°C
• Melting Point: 170℃
• Refractive Index: 1.6800 (estimate)
• Boiling Point: 618°Cat760mmHg
• PKA: pKa (20°C) 7.2
• Flash Point: 327.6°C
• PSA: 91.68000
• Density: 1.428g/cm³
• LogP: 3.21480
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility.: 38.46g/L(temperature not stated)
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 372.0876847
• Heavy Atom Count: 26
• Complexity: 467

Purity/Quality:

99% ^*data from raw suppliers

Glafenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion. Human systemic effects.
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC(=CC3=NC=C2)Cl
• Uses: Glafenine is a non-narcotic analgesic agent. Glafenine shows significant antiinflammatory activity. Glafenine is widely used for the treatment of pains of various origins.
• Therapeutic Function: Analgesic

Technology Process of Glafenine

There total 3 articles about Glafenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + α-Glyceryl Anthranilate (71574-35-1) → glafenine (3820-67-5)

Guidance literature:

With hydrogenchloride; In glycerol; at 80 ℃; for 0.666667h;

DOI:10.1055/s-1980-28923

Reference yield:

isatoic anhydride (118-48-9) → glafenine (3820-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / 1 h / 80 °C

2: 75 percent / aq. HCl / glycerol / 0.67 h / 80 °C

With hydrogenchloride; sodium hydroxide; In glycerol;

DOI:10.1055/s-1980-28923

Reference yield:

→ glafenine (3820-67-5)

Guidance literature:

N-(7-Chlor-4-chinolil)-anthranilsaeure-hydrochlorid, BaCO3, α-Glycerinmonochlorhydrin;

upstream raw materials:

4,7-dichloroquinoline

α-Glyceryl Anthranilate

isatoic anhydride

Downstream raw materials:

7-chloroquinoline

α-Glyceryl Anthranilate

Refernces

• 1、 Mihalic,Valles,Kajfez,et al.. "Synthesis and pharmacological activity of some α monoglycerides". . p. 1 - 7,3, 5, 6. Retrieved 2007/10/05.