2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione

Base Information

Chemical Name:2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione
CAS No.:91833-49-7
Molecular Formula:C₁₃H₁₉N₃OS
Molecular Weight:265.379
Hs Code.:
Mol file:91833-49-7.mol

Synonyms:rocastine;2-(dimethylamino)ethyl-2,3-dihydro-4-methylpyrido-[3,2-f]-1,4-oxazepine-5(4 H)-thione;AHR 11325;2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione;8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-9-oxa-1,6-diaza-benzocycloheptene-5-thione;

Suppliers and Price of 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione

Chemical Property:

Melting Point:130-133 °C
Boiling Point:379.0±52.0 °C(Predicted)
PKA:9.18±0.28(Predicted)
PSA：60.69000
Density:1.20±0.1 g/cm3(Predicted)
LogP:1.33950

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione

There total 5 articles about 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13220-33-2,99445-21-3
1-methyl-3-pyrrolidinol

: 91833-49-7
AHR 11325

Guidance literature:: Multi-step reaction with 4 steps

1: 185 g / NaH / dimethylsulfoxide / 1.5 h / 60 °C

2: 1) HCl(g), 2) triphenylphosphine, CCl₄ / 1) CHCl₃ -> pH 6, 2) reflux, 1.5 h

3: 44 percent / P₄S₁₀ / CHCl₃ / 18 h / Heating

4: ethanol; H₂O / 18 h / 100 °C

With hydrogenchloride; tetrachloromethane; tetraphosphorus decasulfide; sodium hydride; triphenylphosphine; In ethanol; chloroform; water; dimethyl sulfoxide;
DOI:10.1021/jm00129a026

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 91833-49-7
AHR 11325

Guidance literature:: Multi-step reaction with 4 steps

1: 185 g / NaH / dimethylsulfoxide / 1.5 h / 60 °C

2: 1) HCl(g), 2) triphenylphosphine, CCl₄ / 1) CHCl₃ -> pH 6, 2) reflux, 1.5 h

3: 44 percent / P₄S₁₀ / CHCl₃ / 18 h / Heating

4: ethanol; H₂O / 18 h / 100 °C

With hydrogenchloride; tetrachloromethane; tetraphosphorus decasulfide; sodium hydride; triphenylphosphine; In ethanol; chloroform; water; dimethyl sulfoxide;
DOI:10.1021/jm00129a026

Reference yield:

: 2-<(1-methyl-3-pyrrolidinyl)oxy>-3-pyridinecarboxylic acid sodium salt

: 91833-49-7
AHR 11325

Guidance literature:: Multi-step reaction with 3 steps

1: 1) HCl(g), 2) triphenylphosphine, CCl₄ / 1) CHCl₃ -> pH 6, 2) reflux, 1.5 h

2: 44 percent / P₄S₁₀ / CHCl₃ / 18 h / Heating

3: ethanol; H₂O / 18 h / 100 °C

With hydrogenchloride; tetrachloromethane; tetraphosphorus decasulfide; triphenylphosphine; In ethanol; chloroform; water;
DOI:10.1021/jm00129a026