1,3-bis(4-methoxyphenyl)isobenzofuran

Base Information

• Chemical Name: 1,3-bis(4-methoxyphenyl)isobenzofuran
• CAS No.: 6306-97-4
• Molecular Formula: C22H18 O3
• Molecular Weight: 330.383
• Hs Code.: 2932999099
• Mol file: 6306-97-4.mol

Synonyms:NSC 41659

Chemical Property of 1,3-bis(4-methoxyphenyl)isobenzofuran

Chemical Property:

• Vapor Pressure: 1.44E-09mmHg at 25°C
• Boiling Point: 498.1°C at 760 mmHg
• Flash Point: 265.8°C
• PSA: 31.60000
• Density: 1.159g/cm³
• LogP: 5.78400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-bis(4-methoxyphenyl)isobenzofuran

There total 13 articles about 1,3-bis(4-methoxyphenyl)isobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy-3H-isobenzofuran-1-one (4122-57-0) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 1,3-bis(4-methoxyphenyl)isobenzofuran (6306-97-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-2006-948179

Reference yield: 76.9%

methyl o-formylbenzoate (4122-56-9) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 1,3-bis(4-methoxyphenyl)isobenzofuran (6306-97-4)

Guidance literature:

methyl o-formylbenzoate; 4-methoxyphenyl magnesium bromide; In tetrahydrofuran; at -40 - 0 ℃; for 1h;

With trifluoroacetic acid; In tetrahydrofuran; at 25 ℃; for 1.5h;

DOI:10.1246/cl.130398

Reference yield: 30.0%

[2-Diethylamino-6-(4-methoxy-benzoyl)-cyclohex-3-enyl]-(4-methoxy-phenyl)-methanone (74322-73-9) → 1,3-bis(4-methoxyphenyl)isobenzofuran (6306-97-4)

Guidance literature:

With PPA; at 110 ℃; for 0.166667h;

DOI:10.1055/s-1980-28946

upstream raw materials:

3-(4-methoxyphenyl)phthalide

(4-methoxyphenyl)magnesium iodide

acide (dimethoxy-4'4 diphenylmethyl)-2 benzoique

acetic anhydride

Downstream raw materials:

9,14-di-(4'-methoxyphenyl)dibenzanthracene

1,4-bis-(4-methoxyphenyl)naphthalene

6,11-bis(4-methoxyphenyl)benzo[b]naphtho[2,3-d]thiophene S,S-dioxide

5,13-bis(4-methoxyphenyl)dinaphtho[2,3-b:2',3'-d]thiophene S,S-dioxide

Refernces

• 1、 Amaladass,Kumar, Natarajan Senthil,Mohanakrishnan, Arasambattu K.. "Synthesis and characterization of 1,3-diarylbenzo[c]selenophenes". . p. 7992 - 7998. Retrieved 2008/12/20.
• 2、 Oida, Tatsuo,Tanimoto, Shigeo,Sugimoto, Toyonari,Okano, Masaya. "A New Synthesis of 1,3-Diarylisobenzofurans". . p. 131 - 133. Retrieved 2007/10/02.