2,3-Butadienoic acid, 4-phenyl-, ethyl ester

Base Information

• Chemical Name: 2,3-Butadienoic acid, 4-phenyl-, ethyl ester
• CAS No.: 91962-64-0
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Mol file: 91962-64-0.mol

Synonyms:

Chemical Property of 2,3-Butadienoic acid, 4-phenyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-Butadienoic acid, 4-phenyl-, ethyl ester

There total 12 articles about 2,3-Butadienoic acid, 4-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diazoacetic acid ethyl ester (623-73-4) + phenylacetylene (536-74-3) → ethyl 4-phenylbuta-2,3-dienoate (91962-64-0) + ethyl 4-phenylbut-3-ynoate (37174-94-0)

Guidance literature:

diazoacetic acid ethyl ester; phenylacetylene; With copper(l) iodide; In acetonitrile; at 20 ℃; for 12h;

With pyridinium hydrobromide perbromide; In chloroform;

DOI:10.1002/anie.200454070

Reference yield: 66.0%

phenylacetyl chloride (103-80-0) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl 4-phenylbuta-2,3-dienoate (91962-64-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Schlenk technique;

DOI:10.1055/s-0037-1610023

Reference yield: 32.0%

diazoacetic acid ethyl ester (623-73-4) + 4-methylphenylboronic acid (5720-05-8) + phenylacetylene (536-74-3) → ethyl 4-phenylbuta-2,3-dienoate (91962-64-0) + ethyl 4-phenylbut-3-ynoate (37174-94-0) + (E)-ethyl 4-phenyl-3-(p-tolyl)but-3-enoate

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate; In ethyl acetate; at 100 ℃; for 1.5h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9cc07461a

upstream raw materials:

diazoacetic acid ethyl ester

phenylacetylene

phenylacetyl chloride

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

(1S,2S,4R)-3-[1-Phenyl-meth-(E)-ylidene]-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid ethyl ester

(2'R,3S,4S) ethyl 3'-benzoyl-5'-oxo-2',3-diphenyl-spiro[cyclopent-1ene-4,4'-oxazolidine]carboxylate