1-Phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanol

Base Information

• Chemical Name: 1-Phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanol
• CAS No.: 132416-36-5
• Molecular Formula: C17H27 N O2
• Molecular Weight: 277.407
• DSSTox Substance ID: DTXSID80699774
• Mol file: 132416-36-5.mol

Synonyms:132416-36-5;1-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanol;2,2,6,6-TETRAMETHYL-1-(1-PHENYLETHOXY)-;DTXSID80699774;HTXYDPFOHWAMGH-UHFFFAOYSA-N;FT-0740864;1-Phenyl-2-[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]ethan-1-ol

Chemical Property of 1-Phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanol

Chemical Property:

• PSA: 32.70000
• LogP: 3.63260
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 277.204179104
• Heavy Atom Count: 20
• Complexity: 292

Purity/Quality:

98%min ^*data from raw suppliers

4-HYDROXY-1-((1'-PHENYLETHYL)OXY)-2,2,6,6-TETRAMETHYLPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCC(N1OCC(C2=CC=CC=C2)O)(C)C)C

Technology Process of 1-Phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanol

There total 10 articles about 1-Phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-benzoyloxy-2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidine → 4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine (132416-36-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 16h; Heating;

DOI:10.1021/ja9624228

Reference yield: 80.2%

TEMPOL (45985-24-8,2226-96-2) + (1-bromoethyl)benzne (585-71-7,38661-81-3) → 4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine (132416-36-5)

Guidance literature:

TEMPOL; With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper; copper(I) bromide; In methoxybenzene; for 0.0833333h;

(1-bromoethyl)benzne; In methoxybenzene; for 18h;

DOI:10.1021/ma102313q

Reference yield: 80.2%

4-hydroxy-TEMPO + (1-bromoethyl)benzne (585-71-7,38661-81-3) → 4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine (132416-36-5)

Guidance literature:

4-hydroxy-TEMPO; With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper; methoxybenzene; copper(I) bromide; for 30h; Schlenk technique; Inert atmosphere;

(1-bromoethyl)benzne; at 40 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c5cc02420j

upstream raw materials:

TEMPOL

ethylbenzene

4-(benzyloxycarbonyl)-2,2,6,6-tetramethylpiperidine-1-oxyl

tempol

Downstream raw materials:

C₂₀H₃₀BrNO₃

1-Phenylethanol

[2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate

bis[2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl]succinic acid