[2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate

Base Information

• Chemical Name: [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate
• CAS No.: 1403757-28-7
• Molecular Formula: C₂₂H₃₅NO₃
• Molecular Weight: 361.525
• Mol file: 1403757-28-7.mol

Synonyms:[2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate

Chemical Property of [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate

There total 3 articles about [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pentanoic anhydride (2082-59-9) + 4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine (132416-36-5) → [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate (1403757-28-7)

Guidance literature:

With dmap; In dichloromethane; at 3 - 22 ℃; for 14h;

Reference yield:

tert-butyl methyl ether (1634-04-4) + pentanoic anhydride (2082-59-9) + 4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine (132416-36-5) → [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate (1403757-28-7)

Guidance literature:

With hydrogenchloride; triethylamine; In dichloromethane; water;

Reference yield:

TEMPOL (45985-24-8,2226-96-2) → [2,2,6,6-tetramethyl-1-(1-phenylethoxy)piperidin-4-yl] pentanoate (1403757-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) chloride; dihydrogen peroxide / tert-butyl alcohol / 16 h / 22 - 30 °C

2: dmap / dichloromethane / 14 h / 3 - 22 °C

With dmap; dihydrogen peroxide; copper(l) chloride; In dichloromethane; tert-butyl alcohol;

upstream raw materials:

tert-butyl methyl ether

pentanoic anhydride

4-hydroxy-1-((1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine

TEMPOL