3-METHYL-1,4-DIPHENYL-1H-PYRAZOL-5-AMINE

Base Information

• Chemical Name: 3-METHYL-1,4-DIPHENYL-1H-PYRAZOL-5-AMINE
• CAS No.: 58314-81-1
• Molecular Formula: C16H15N3
• Molecular Weight: 249.315
• Hs Code.: 2933199090
• Mol file: 58314-81-1.mol

Synonyms:3-Methyl-1,4-diphenyl-1H-pyrazol-5-amine;5-methyl-2,4-diphenyl-2H-pyrazol-3-ylamine;5-Methyl-2,4-diphenyl-2H-pyrazol-3-ylamin;3-methyl-1,4-diphenylpyrazole-5-ylamine;5-amino-3-methyl-1,4-diphenylpyrazole;

Chemical Property of 3-METHYL-1,4-DIPHENYL-1H-PYRAZOL-5-AMINE

Chemical Property:

• Vapor Pressure: 5.68E-07mmHg at 25°C
• Boiling Point: 411.2°Cat760mmHg
• Flash Point: 202.5°C
• PSA: 43.84000
• Density: 1.15g/cm³
• LogP: 4.01110

Purity/Quality:

99%min ^*data from raw suppliers

3-METHYL-1,4-DIPHENYL-1H-PYRAZOL-5-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-1,4-DIPHENYL-1H-PYRAZOL-5-AMINE

There total 3 articles about 3-METHYL-1,4-DIPHENYL-1H-PYRAZOL-5-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylhydrazine (100-63-0) + 1-phenyl-1-cyanopropan-2-one (4468-48-8) → 3-methyl-1,4-diphenyl-1H-pyrazol-5-amine (58314-81-1)

Guidance literature:

With toluene-4-sulfonic acid; In water; at 110 ℃; for 3h;

DOI:10.1002/jhet.4439

Reference yield: 55.0%

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + phenylboronic acid (98-80-6) → 3-methyl-1,4-diphenyl-1H-pyrazol-5-amine (58314-81-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; sodium hydrogencarbonate; In ethanol; water; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2012.02.007

Reference yield:

→ 3-methyl-1,4-diphenyl-1H-pyrazol-5-amine (58314-81-1)

Guidance literature:

/BRN= 5049/;

upstream raw materials:

1-Phenyl-3-methyl-5-aminopyrazole

phenylboronic acid

phenylhydrazine

1-phenyl-1-cyanopropan-2-one

Downstream raw materials:

1-methyl-3-phenyl-3,4-dihydro-pyrazolo[3,4-c]isoquinolin-5-one

Refernces

• 1、 Lv, Ting,Zhang, Xiao-Hong,Han, Jiang-Sheng,Zhong, Ping. "Pd-catalyzed direct arylation of phenylpyrazole: Synthesis of fipronil derivatives with aryl boronic acids promoted by a stoichiometric amount of NIS". experimental part. p. 44 - 49. Retrieved 2012/05/05.